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Pregled bibliografske jedinice broj: 778381

DEVELOPMENT OF HPLC METHOD FOR IMPURITY PROFILING OF 7-ETHYLTRYPTOPHOL-THE FIRST STEP IN AN LC-SPE-NMR APPROACH

Habinovec, Iva; Car, Željka; Ribić, Rosana; Biljan, Ivana; Pičuljan, Katarina; Galić, Nives; Novak, Predrag; Tomić, Srđanka; Meštrović, Ernest
DEVELOPMENT OF HPLC METHOD FOR IMPURITY PROFILING OF 7-ETHYLTRYPTOPHOL-THE FIRST STEP IN AN LC-SPE-NMR APPROACH // Programme & Book of Abstract, Pharma NMR Conference, Application of NMR Spectroscopy in Pharmaceutical Industry / Novak, Predrag ; Tomišić, Vladislav ; Bregović, Nikola (ur.).
Zagreb: International Association of Physical Chemists (IAPC), 2015. str. 25-25 (poster, domaća recenzija, sažetak, ostalo)

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Naslov
DEVELOPMENT OF HPLC METHOD FOR IMPURITY PROFILING OF 7-ETHYLTRYPTOPHOL-THE FIRST STEP IN AN LC-SPE-NMR APPROACH

Autori
Habinovec, Iva ; Car, Željka ; Ribić, Rosana ; Biljan, Ivana ; Pičuljan, Katarina ; Galić, Nives ; Novak, Predrag ; Tomić, Srđanka ; Meštrović, Ernest

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Programme & Book of Abstract, Pharma NMR Conference, Application of NMR Spectroscopy in Pharmaceutical Industry / Novak, Predrag ; Tomišić, Vladislav ; Bregović, Nikola - Zagreb : International Association of Physical Chemists (IAPC), 2015, 25-25

Skup
Pharma NMR Conference, Application of NMR Spectroscopy in Pharmaceutical Industry

Mjesto i datum
Rovinj, Hrvatska, 23.09.2015. - 25.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
7-Ethyltryptophol; Purity; Structures of impurities; HPLC method; LC-SPE-NMR analysis

Sažetak
7-Ethyltryptophol, 2(7-ethyl-1H-indol-3- yl)ethanol, is a key starting material in the synthesis of Etodolac, a non-steroidal anti- inflammatory drug (Scheme 1). Depending on the synthetic pathway for 7- ethyltryptophol, commercially available material comprises many different impurities which can cause formation of coproducts in the synthesis of Etodolac thus complicating the purification of the final product.[1] Therefore, to develop an optimal purification procedure of Etodolac, it is important to know the structures of impurities in 7- ethyltryptophol. LC-SPE-NMR methodology is a powerful tool for fast identification and structural elucidation of low concentration level impurities and degradation products in pharmaceuticals.[2] In this study we report on the HPLC method for efficient separation of impurities in 7- ethyltryptophol as the first step in hyphenated LC-SPE-NMR analysis. References 1. M. C. Sekharayya, G. V. Narayana, S. Nigam, G. Madhusudhan, Indian J. Chem. 51B (2012) 1763-1766. 2. S. Singh, T. Handa, M. Narayanam, A. Sahu, M. Junwal, R. P. Shah, J. Pharm. Biomed. Anal. 69 (2012) 148-173. Acknowledgements: This work was funded by European Regional Development Fund and Croatian state budget (project Met4Pharm).

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Nives Galić (autor)

Avatar Url Iva Habinovec (autor)

Avatar Url Ivana Biljan (autor)

Avatar Url Rosana Ribić (autor)

Avatar Url Katarina Pičuljan (autor)

Avatar Url Srđanka Tomić-Pisarović (autor)

Avatar Url Predrag Novak (autor)

Avatar Url Željka Car (autor)

Avatar Url Ernest Meštrović (autor)

Citiraj ovu publikaciju:

Habinovec, Iva; Car, Željka; Ribić, Rosana; Biljan, Ivana; Pičuljan, Katarina; Galić, Nives; Novak, Predrag; Tomić, Srđanka; Meštrović, Ernest
DEVELOPMENT OF HPLC METHOD FOR IMPURITY PROFILING OF 7-ETHYLTRYPTOPHOL-THE FIRST STEP IN AN LC-SPE-NMR APPROACH // Programme & Book of Abstract, Pharma NMR Conference, Application of NMR Spectroscopy in Pharmaceutical Industry / Novak, Predrag ; Tomišić, Vladislav ; Bregović, Nikola (ur.).
Zagreb: International Association of Physical Chemists (IAPC), 2015. str. 25-25 (poster, domaća recenzija, sažetak, ostalo)
Habinovec, I., Car, Ž., Ribić, R., Biljan, I., Pičuljan, K., Galić, N., Novak, P., Tomić, S. & Meštrović, E. (2015) DEVELOPMENT OF HPLC METHOD FOR IMPURITY PROFILING OF 7-ETHYLTRYPTOPHOL-THE FIRST STEP IN AN LC-SPE-NMR APPROACH. U: Novak, P., Tomišić, V. & Bregović, N. (ur.)Programme & Book of Abstract, Pharma NMR Conference, Application of NMR Spectroscopy in Pharmaceutical Industry.
@article{article, author = {Habinovec, Iva and Car, \v{Z}eljka and Ribi\'{c}, Rosana and Biljan, Ivana and Pi\v{c}uljan, Katarina and Gali\'{c}, Nives and Novak, Predrag and Tomi\'{c}, Sr\djanka and Me\v{s}trovi\'{c}, Ernest}, year = {2015}, pages = {25-25}, keywords = {7-Ethyltryptophol, Purity, Structures of impurities, HPLC method, LC-SPE-NMR analysis}, title = {DEVELOPMENT OF HPLC METHOD FOR IMPURITY PROFILING OF 7-ETHYLTRYPTOPHOL-THE FIRST STEP IN AN LC-SPE-NMR APPROACH}, keyword = {7-Ethyltryptophol, Purity, Structures of impurities, HPLC method, LC-SPE-NMR analysis}, publisher = {International Association of Physical Chemists (IAPC)}, publisherplace = {Rovinj, Hrvatska} }
@article{article, author = {Habinovec, Iva and Car, \v{Z}eljka and Ribi\'{c}, Rosana and Biljan, Ivana and Pi\v{c}uljan, Katarina and Gali\'{c}, Nives and Novak, Predrag and Tomi\'{c}, Sr\djanka and Me\v{s}trovi\'{c}, Ernest}, year = {2015}, pages = {25-25}, keywords = {7-Ethyltryptophol, Purity, Structures of impurities, HPLC method, LC-SPE-NMR analysis}, title = {DEVELOPMENT OF HPLC METHOD FOR IMPURITY PROFILING OF 7-ETHYLTRYPTOPHOL-THE FIRST STEP IN AN LC-SPE-NMR APPROACH}, keyword = {7-Ethyltryptophol, Purity, Structures of impurities, HPLC method, LC-SPE-NMR analysis}, publisher = {International Association of Physical Chemists (IAPC)}, publisherplace = {Rovinj, Hrvatska} }

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