Naslov
Comparative phytochemical analysis of four Globularia spp.

Autori
Crkvenčić, Maja ; Bucar, Franz ; Hazler Pilepić, Kroata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
24th Scientific Congress of the Austrian Pharmaceutical Society (OePhG) / - Beč : Austrian Pharmaceutical Society, 2015, 60-60

Skup
24th Scientific Congress of the Austrian Pharmaceutical Society (OePhG)

Mjesto i datum
Beč, Austrija, 12.09.2015. - 14.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Globularia ; phytochemistry ; LC-DAD-ESI-MSn

Sažetak
Globularia alypum L. is a medicinal plant often used in folk medicine of Mediterranean countries for treatment of diabetes, digestive disorders and eczema [1, 2]. Its biological activities can be connected to the presence of different phenolic and iridoid compounds [3]. The aim of the present study was to compare the phytochemical composition of three related Globularia species to that of G. alypum, in order to evaluate their pharmaceutical potential. Chemical composition of methanolic extracts of G. alypum L., G. cordifolia L., G. meridionalis (Podp.) O. Schwarz and G. punctata Lapeyr. obtained by boiling under reflux conditions was compared for the first time using LC-DAD-ESI-MSn. Main components were identified by comparison of their retention time, UV and mass spectra (including MSn up to MS4) to those of reference compounds and/or to literature data. Considering iridoid composition, catalpol and 10- O-esters of catalpol were characteristic for G. alypum and G. punctata, while 6-O-catalpol esters were observed only in G. alypum. High levels of globularin were observed in both species. Monomelittoside and its esters were characteristic for G. cordifolia and G. meridionalis extracts, with globularifolin present as a major compound. High amounts of asperuloside were observed in G. cordifolia, G. meridionalis and G. punctata, among which G. punctata contained high amounts of besperuloside, as well. All four species contained a large number of phenylethanoids, with verbascoside being the most abundant. Additionally, G. punctata contained high amounts of trichosanthoside A. High amounts of bioactive compounds such as globularin [4], globularifolin [5] and verbascoside [6], observed in G. cordifolia, G. meridionalis and G. punctata suggest these species have potential for further exploitation.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA