Naslov
Human papillomaviruses in oral cavity cancers in Croatian patients

Autori
Dediol, Emil ; Sabol, Ivan ; Manojlovic, Spomenka ; Grce, Magdalena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
29th International Papillomavirus Conference and Clinical & Public Health Workshops / Denise A. Galloway - , 2014, 181-181

Skup
29th International Papillomavirus Conference and Clinical & Public Health Workshops

Mjesto i datum
Seattle (WA), Sjedinjene Američke Države, 20.08.2014. - 25.08.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HPV ; Oral ; HNSCC

Sažetak
The major risk factor for oral cavity cancer is the longstanding alcohol intake and tobacco consumption. However, about 10% of oral cavity cancer patients are never-drinker and never- smoker (NDNS). Indeed, in developed countries there is a rising trend of oral cancer in spite of decreasing alcohol and tobacco consumption. Since human papillomaviruses (HPVs) have been linked to oropharyngeal cancer, especially in NDNS, there is a possibility of HPV association and oral cancer as well. Thus, the purpose of this study was to evaluate the frequency of HPV types, especially type 16, in oral cavity cancer patients to confirm the above mentioned hypothesis. In total 154 formalin-fixed and paraffinembedded(FFPE) oral cavity cancer tissues were enrolled in the study, of which 77 cases from NDNS patients. HPV was detected by PCR with specifically designed primers for FFPE samples, i.e. very short SPF broad spectrum primers with extension for further sequencing of amplicons of about 66 bp. In total 27% of all oral cancer patients were HPV positive. Surprisingly, HPV was more frequent among alcohol drinkers and tobacco smokers than NSND patients, 31% versus 22% , respectively. Men were more frequently HPV positive (68%) than women, who were more NSND. HPV positive patients were slightly younger (56 versus 60 years) than HPV negative. As expected, HPV16 was the most common type found in 39% positive samples, followed by HPV31 (10%). There were 14 samples (24%) with more than one HPV type of which 10 could not be resolved. In conclusion, this study supports the causal relationship between high-risk HPV types and a subset of oral cavity cancer.

Izvorni jezik
Engleski

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