Pregled bibliografske jedinice broj: 774203
Methicillin-resistant S. aureus (MRSA), extended-spectrum (ESBL)- and plasmid-mediated AmpC ß-lactamase -producing Gram-negative bacteria associated with skin and soft tissue infections in hospital and community settings.
Methicillin-resistant S. aureus (MRSA), extended-spectrum (ESBL)- and plasmid-mediated AmpC ß-lactamase -producing Gram-negative bacteria associated with skin and soft tissue infections in hospital and community settings. // Medicinski glasnik Ljekarske komore Zeničko-dobojskog kantona, 12 (2015), 2; 157-168 (međunarodna recenzija, članak, znanstveni)
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Naslov
Methicillin-resistant S. aureus (MRSA), extended-spectrum (ESBL)- and plasmid-mediated AmpC ß-lactamase -producing Gram-negative bacteria associated with skin and soft tissue infections in hospital and community settings.
Autori
Uzunović, Selma ; Bedenić, Branka ; Budimir, Ana ; Ibrahimagić, Amir ; Kamberović, Fara ; Fiolić, Zlatko ; Rijnders, Anna ; Stobberingh, Ellen
Izvornik
Medicinski glasnik Ljekarske komore Zeničko-dobojskog kantona (1840-0132) 12
(2015), 2;
157-168
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
CTX-M beta-lactamase ; MLST CC152 ; antibiotic resistance ; surgical wound infection
Sažetak
Abstract Aim To investigate the characteristics of meticillin-resistant S. aureus (MRSA), extended-spectrum (ESBL), and plasmid-mediated AmpC beta-lactamase producing Gram-negative bacteria causing skin and soft tissue infections (SSTIs) in hospital and outpatient settings of Zenica-Doboj Canton, Bosnia and Herzegovina. Methods Antibiotic susceptibility was determined by disc-diffusion and broth microdillution methods according to CLSI guidelines. MecA gene was detected by PCR, and genetic characterization of MRSA was performed using spa-typing and the algorithm based upon repeat patterns (BURP). Double-disk-synergy test was used to screen for ESBLs. PCR was used to detect blaESBL alleles. Genetic relatedness of the strains was tested by PFGE. Results Seventeen in-patients with MRSA, 13 with ESBL-producing Gram-negative bacteria and three patients co-infected with both, were detected. Five MRSA and 16 ESBL-producing Gram-negative bacteria were found in outpatient samples. Klebsiella spp. was isolated in 11 in- and seven outpatients. MLST CC152 was the most prevalent MRSA. Seven (38.9%) Klebsiella spp. yielded amplicons with primers specific for SHV, TEM-1 and CTX-M group 1 β-lactamases. Eight K. pneumonia (44.4%) and 16 (64%) MRSA (including the in- and outpatient) strains were clonally related. Conclusion The presence of MRSA and ESBL-producing organisms causing SSTIs in the community poses a substantial concern, due to the high morbidity and mortality associated with possible consequent hospital infections.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
108-1080114-0015 - Mehanizmi rezistencije na antibiotike u Gram-negativnih bakterija (Bedenić, Branka, MZOS ) ( CroRIS)
108-1080114-0017 - Genotipovi i činitelji virulencije uzročnika bolničkih infekcija (Budimir, Ana, MZOS ) ( CroRIS)
121-1080114-0306 - Djelovanje antibiotika na uzročnike biofilm infekcija (Vraneš, Jasmina, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar"
Citiraj ovu publikaciju:
Časopis indeksira:
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Index Medicus, Scopus
