Naslov
The impact of population differentiation on statistical forensic parameters of STRs in the South-Eastern Europe region

Autori
Novokmet, Natalija ; Marjanović, Damir ; Havaš Auguštin, Dubravka ; Šarac, Jelena ; Šarić, Tena ; Škaro, Vedrana ; Projić, Petar ; Vidovič, Maruška ; Missoni, Saša ; Rudan, Pavao

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
9th ISABS Conference on Forensic, Anthropologic Genetics and Mayo Clinic Lectures in Individualized Medicine / Kayser, Manfred ; Ördög Tamas ; Vuk-Pavlović, Stanimir ; Primorac, Dragan ; Schanfield, Moses - Zagreb : International Society for Applied Biological Sciences (ISABS), 2015, 127-127

Skup
9th ISABS Conference on Forensic, Anthropologic Genetics and Mayo Clinic Lectures in Individualized Medicine

Mjesto i datum
Bol, Hrvatska, 2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
population isolates; forensic parameters; STR markers; DNA database; South-Eastern Europe

Sažetak
The presence of physical and cultural barriers to gene flow influences genetic differentiation between two localized subpopulations. Specifically, isolation of a population from its neighbors by geographical barriers such as the sea reduces genetic interactions between the populations and leads to higher RST values. Furthermore, the presence of certain cultural barriers to gene flow, and social practices such as endogamy, also result in increased levels of population differentiation. In this study the data obtained by the analysis of 9 autosomal STR loci in Croatian islands and Slovenian populations were integrated with the published data from other Croatian islands and wide SE European region. The sample was defined hierarchically and the influence of isolation of the Croatian islands subpopulations on substructuring of the population of Croatia, as well as the influence of the regional population groups on substructuring of South- Eastern Europe was detected. Due to the decreased influence of endogamy, lower genetic differentiation was detected at the higher level of grouping of SE European populations (RST = 0, 002) than at the level of sub- populations of Croatia (RST = 0, 005). Finally, the influence of substructuring of the aforementioned levels on the calculation of forensic statistical parameters was determined. It was found that the isolation of Croatian insular populations affects the value of forensic parameters. These findings indicate that adequate sampling of the entire subpopulation is needed to create representative DNA database of genetic STR markers that would reflect all characteristics of its subpopulations.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA