Naslov
Risk for de novo sensitisation to ragweed in Croatian children

Autori
Večenaj, Ana ; Miletić Gospić, Adrijana ; Perica, Marija ; Banić, Ivana ; Živković, Jelena ; Plavec, Davor ; Turkalj, Mirjana.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Third International Ragweed Conference(IRC)

Mjesto i datum
Milano, Italija, 03.04.2014. - 04.04.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
children ; ragweed ; aeroallergens

Sažetak
FP7 project ATOPICA (Atopic diseases in changing climate, land use and air quality) supported by EU Grant agreement NO: CP 282687 explores the combined pan-European impact of changes in climate, land use and air pollution on allergen pollen-induced diseases with an accent on atopy due to ragweed sensitization. Sensitization to ragweed pollen correlates with levels of airborne pollen concentration in environment, but can be enhanced by other environmental factors such as air pollution. Cohort of 3590 children, aged 4-10 years, was recruited from 3 regions of Croatia differing in airborne pollen concentrations (Slavonia, Zagreb and surrounding end Dalmatia). Each participant underwent skin prick test (SPT) to the standard set of aeroallergens. For each region, pollen concentrations and air quality data were gathered from authorized institutions. A total of 369 children were sensitized to ragweed pollen. Prevalence of ragweed sensitization was 14.84 % in Zagreb area, 14.26 % in Slavonia and 1.52 % in Dalmatia. Comparing the highest pollen concentrations during ragweed pollinating period among 3 regions, Dalmatia has the lowest concentration of ragweed pollen of 30-40 grains/m3, while Zagreb measures 250-300 grains/m3 and Slavonia 700-1000 grains/m3 per 24 hours. Analysis of sensitization in two age groups (4-6 and 7-10 years) reveals higher prevalence of ragweed, birch and D. pteronyssinus sensitization as well as double sensitization (birch and ragweed) in older age group for all 3 regions. Sensitization to above allergens was more prevalent in male participants. After two pollen seasons of follow-up, de novo sensitized children were recorded: 2.88% in Zagreb area, 2, 73% in Slavonia and 0, 00% in Dalmatia. Analysis of de novo sensitization in two age groups shows more de novo sensitized children in older age group for all regions. Pollen diary data (data on overall simptom score, eyes, nose, lungs symptoms/problems, usage of medicine and daily activity) also showed correlation between ragweed pollen concentrations and severity of symptoms. Region of Slavonia measures highest ragweed pollen concentrations and also most de novo sensitized children, which leads to assumption that de novo sensitization rates are primary correlated to exposure levels to ragweed pollen.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA