Naslov
Hair as a novel long term biological indicator for assessing the human Na and K nutritional status

Autori
Momčilović, Berislav ; Prejac, Juraj ; Višnjević, Vjeran ; Mimica, Ninoslav ; Skalny, Anatoly V

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Experimental Biology 2015 - Transforming the Future through Science - Abstracts of the Annual Meeting of American Society for Nutrition (ASN) / American Society for Nutrition (ASN) - Bethesda (MD) : Federation of American Societies for Experimental Biology (FASEB), 2015, 204-204

Skup
Annual Meeting of American Society for Nutrition (ASN)

Mjesto i datum
Boston (MA), Sjedinjene Američke Države, 28.03.2015. - 01.04.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hair; indicator; biological; long term; status; nutritional; human; Na; K

Sažetak
How much sodium (Na) and potassium (K) should be in the human diet so that it would not be accompained with cardiovascular events is a perenial epidemiology challenge. Urinary Na and K are the standard short term biological indicators of Na and K dietary exposure. In this study we have assessed Na and K population status from frequency distribution properties of their concentration in the hair as a long term biological indicator. The study was conducted according to the Basic Principles of the Declaration of Helsinki. Na and K were analyzed in 1072 hair samples of healthy adult subjects (733 [female]and 339 [male]) with ICP MS and ICP EMS, respectively. The median values (μg•g­1) were Na ([female]254 and [male]371) and K ([female]74.3 and [male]143), respectively ; the log transformed data were analyzed with the method of median derivatives (Thyroid 2014 ; 24:1018­1026). The observed sigmoid curves had a linear range: Na ([female] 55, 6 ­ 1307, [male] 84.0 – 1450), K ([female] 18.9 – 467, [male] 25.8 – 1079). This linear and adequate segment of hair saturation with Na and K is itself an exponential 3­compartment Michaelis­Menton kinetic model, where the respective sparse, true, and ample adequate Na and K hair deposition may be identified. We propose that the human true adequate Na and/or K hair concentrations should be: Na ([female] 420 – 563, [male] 790 ­ 975), K ([female] 142 – 283, [male] 286 ­ 588).This is the first personalized human Na and K assessment based on the results of their intermediary metabolic response.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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