Naslov
DEVELOPMENT OF HPLC METHOD FOR MONITORING ACID- CATALYZED CONVERSION OF 7-ETHYLTRYPTOPHOL TO METHYL ESTER OF ETODOLAC

Autori
Habinovec, Iva ; Car, Željka ; Ribić, Rosana ; Biljan, Ivana ; Galić, Nives ; Novak, Predrag ; Tomić, Srđanka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
19TH EUROPEAN SYMPOSIUM ON ORGANIC CHEMISTRY, BOOK OF ABSTRACTS / Rauter, Amélia P. ; Martins, Alice ; Matos, Ana M. ; Dias, Catarina ; Xavier, Nuno M. ; Nunes, Rafael ; Lucas, Susana D. ; Cachatra, Vasco ; Paiva, Ana P. ; Batista, Daniela - Lisabon : Ricardo Avella, 2015, 592-592

ISBN
978-989-8124-11-1

Skup
19TH EUROPEAN SYMPOSIUM ON ORGANIC CHEMISTRY

Mjesto i datum
Lisabon, Portugal, 12.07.2015. - 16.07.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HPLC method; kinetic study; Oxa Pictet Spengler reaction

Sažetak
Etodolac methyl ester is a key intermediate in the synthesis of Etodolac, a non-steroidal anti-inflammatory drug. It can be obtained by oxa-Pictet-Spengler reaction, starting from 7- ethyltriptophol and using inorganic mineral acids as catalysts.[1] In order to get kinetic profiles of reactions catalyzed with different molar ratios of sulfuric and hydrochloric acid, a high performance liquid chromatography method with UV detection was developed for monitoring conversion of 7-ethyltryptophol to methyl ester of Etodolac. For that purpose different stationary phases (C18, Phenyl and NH2 column) were investigated for separation of 7-ethyltryptophol and Etodolac methyl ester. Elution was performed with three different solvent mixtures in isocratic and/or gradient mode. The best chromatographic separation was achieved isocratically using Waters Symmetry Shield RP 18 column with 55% acetonitrile and 45% water.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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