Naslov
LC-NMR analysis of impurities in a key starting material of Etodolac

Autori
Biljan, Ivana ; Car, Željka ; Jednačak, Tomislav ; Pičuljan, Katarina ; Ribić, Rosana ; Habinovec, Iva ; Galić, Nives ; Tomić, Srđanka ; Novak, Predrag

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
EUROMAR 2015 Programme and Abstract Book / Sklenář, Vladimír - Brno : Masaryk University, 2015, 440-440

ISBN
978-80-210-7890-1

Skup
EUROMAR 2015

Mjesto i datum
Prag, Češka Republika, 05.07.2015. - 10.07.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
LC-NMR; impurities; tryptophols

Sažetak
Tryptophols are derivatives of 2-(1H-indol-3-yl)ethanol, indole class bearing a C-3 hydroxyethyl side chain. 7-Ethyltryptophol, 2-(7-ethyl-1H-indol-3-yl)ethanol, is a key starting material in the synthesis of Etodolac, an important non-steroidal anti-inflammatory drug. The currently available synthetic procedures for 7-ethyltryptophol usually result with formation of a high-level of various impurities. LC-NMR is a very powerful tool for obtaining detailed structural information of components in complex mixtures such as impurities and metabolites in pharmaceuticals, natural products and synthetic polymers. In the present study, we developed LC-NMR methodology for separation and structural analysis of impurities in commercially available 7-ethyltryptophol. Several impurity peaks were detected in chromatograms and the structures of major impurities were elucidated by analyzing 1D and 2D LC-NMR spectra.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA