Naslov
Parametric study of the influence of intraluminal thrombus and collagen stiffness and turnover on the aneurysmal wall

Autori
Virag, Lana ; Vindiš, Vedran ; Wilson, John S. ; Humphrey, Jay D. ; Karšaj, Igor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
9th European Solid Mechanics Conference

Mjesto i datum
Madrid, Španjolska, 06.07.2015. - 10.07.2015

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Growth and remodeling; Abdominal aortic aneurysm; Intraluminal thrombus

Sažetak
Abdominal aortic aneurysm (AAA) is a dilatation of a blood vessel that occurs due to irreversible pathological remodeling of the extracellular matrix. Majority of AAAs includes intraluminal thrombus (ILT). These thrombi have complex natural histories and structures, and their biological and mechanical properties influence growth and remodeling (G&R) of AAAs. Numerous studies were conducted to investigate if ILT can change stress distribution in aortic wall. Recently, there is also increasing evidence that ILT is biologically active and should not be treated as homogeneous inert material. We present you the first attempt to comprehensively model G&R of the thrombus-laden AAAs and influence of changes in primary effectors governing the evolution of the AAA mechanics on its final outcome. Application of model to a cylindrical geometry will help us understand better the way thrombus acts on the aortic wall, and form a hypothesis about the most important aspects on which we must focus after implementation into FEM.

Izvorni jezik
Engleski

Znanstvena područja
Strojarstvo

POVEZANOST RADA