Naslov
Platinum(II) complexes of 2-quinolylmethylphosphonates, Synthesis, characterization and cytostatic activity

Autori
Tušek-Božić, Ljerka ; Meider, Henrika ; Scarcia Vito ; Furlani, Ariella

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
1st Central European Conference "Chemistry towards Biology", Book of Abstracts / Kaučič, Venčeslav ; Mali, Gregor - Ljubljana : Slovenian Chemical Society, 2002, 126-126

Skup
1st Central European Conference "Chemistry towards Biology"

Mjesto i datum
Portorož, Slovenija, 08.09.2002. - 12.09.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
platinum(II) complex; quinolylmethylphosphonate; cytostatic activity

Sažetak
The study of phosphonic and aminophosphonic acid derivatives is of current interest owing to great importance of these compounds in metabolism and some biological processes. Another interesting aspect regarding this kind of compounds arises from their ability of forming different types of metal complexes, which might be also of interest in living systems. In recent years, a number of aminophosphonate complexes of Pt(II) and Pd(II) have been found to possess significant cytostatic activity. Continuing our research on this class of compounds, the synthesis, some spectroscopic properties and cytostatic activity of the novel Pt(II) complexes with diethyl and monoethyl 2-quinolylmethylphosphonate have been reported. These organophosphorus ligands depending on reaction conditions form neutral or ionic Pt(II) complexes. Acting as N-monodentate ligand form dihalide adducts PtL_2X_2, by bonding in the N, O-bidentate manner give PtL_2 chelates, while under acidic conditions are formed the ion-pair salt complexes [(LH)_2(PtX_4)] or [(LH)_2(Pt_2X_6)] (X=Cl, Br), with protonated quinoline ligand as cation and tetrahaloplatinate or hexahalodiplatinate complex as anion. The coordination behaviour of diethyl and monoethyl phosphonates towards Pt(II) ion as well as spectroscopic and biological properties of their Pt(II) complexes were discussed with respect to results obtained for the corresponding Pd(II) derivatives.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA