Naslov
Synthesis, cytostatic and antiviral activity of dialkyl 2-and 3-quinoline-substituted alpha-aminophosphonates

Autori
Tušek-Božić, Ljerka ; Balzarini, Jan ; De Clercq, Erik

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XV International Round Table, Nucleosides, Nucleotides and Nucleic acids, Program and Abstracts / De Clercq, Erik ; Herdewijn, Piet - Leuven : Rega Institute for Medical Research, K. U. Leuven, 2002

Skup
XV International Round Table, Nucleosides, Nucleotides and Nucleic acids

Mjesto i datum
Leuven, Belgija, 10.09.2002. - 14.09.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
aminophosphonate; cytostatic activity; antiviral activity

Sažetak
The chemistry and biochemistry of a-aminophosphonic acids and their derivatives have attracted current interest owing to their wide range of biological properties, with possible application from medicine to agriculture as enzyme inhibitors as well as antibacterial, anticancer and herbicidal agents. Recently, increasing attention has been devoted to nucleoside and nucleotide phosphonate analogues as broad-spectrum antiviral agents. Studying this class of phosphonic acid derivatives, we now report the synthesis, spectroscopic characterization and biological evaluation of novel dialkyl 2- and 3-quinoline-substituted a-aminophosphonates. As a preliminary assessment of their biological activity, complexes were evaluated for their in vitro cytostatic activity against human T-lymphoblast Molt4/C8 and CEM/0 cell lines and the murine leukemia L1210/0 tumor cell line, as well as for in vitro antiviral activity in different assay systems including a broad spectrum of DNA and RNA viruses. None of the examined compounds were found to exhibit cytostatic activity at therapeutically meaningful concentrations.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA