Naslov
Cytokinesis without myosin II

Autori
Gerisch, G. ; Weber, Igor

Izvornik
Current Opinion in Cell Biology (0955-0674) 12 (2000), 1; 126-132

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Sažetak
The ability of substrate-anchored Dictyostelium cells to divide without myosin II has opened the possibility of analysing the formation of cleavage furrows in the absence of a contractile ring made of filamentous myosin and actin. Similar possibilities exist in mutants of budding yeast and, less strictly, also in drug-treated mammalian cells. Myosin-II-independent activities in Dictyostelium include the microtubule-induced programming of the cell surface into ruffling areas and regions that are converted into a concave furrow, as well as the translocation of cortexillins and cross-linked membrane proteins towards the cleavage furrow. A centripetal flow of actin filaments followed by their disassembly in the cleavage furrow is proposed to underlie the translocation.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA