Naslov
Treatment with a glucagon-like peptide-1 receptor agonist exenatide decreases systolic blood pressure in overweight type 2 diabetic patients

Autori
Bulum, Tomislav ; Blaslov, Kristina ; Prkačin, Ingrid ; Zibar, Karin ; Duvnjak, Lea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Hypertension 2015 ; 33 (e-Suppl. 1): e200- e200 / - , 2015

Skup
25th European Meeting on Hypertension

Mjesto i datum
Milano, Italija, 12.06.2015. - 15.06.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
glukagon-like peptide-1; blood pressure; heart rate

Sažetak
Glucagon-like peptide-1 (GLP-1)agonists are increasingly used in the management of type 2 diabetes mellitus (T2DM), but their long- termcardiovascular safety is not yet confirmed. Therapy with GLP-1 receptor agonist exenatide has been associated with improvements in systolic blood pressure(SBP)and with small increases in heart rate(HR)in long-term clinical trials. In the present study, we assessed effects of exenatide on SBP, diastolic blood pressure(DBP)and HR in overweight T2DM. The findings of this study compare well with previous studies and suggest that 22-months administration of exenatide resulted in significant reduction in SBP in overweight T2DM. Experimental studies of GLP-1 analogues have also reported direct effects on blood pressure, possibly via interaction with the autonomic nervous system.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA