Naslov
Acute exhausting exercise session affects microvascular endothelial function in young healthy athletes

Autori
Stupin, Marko ; Čavka, Ana ; Rašić, Lidija ; Ćosić, Anita ; Lenasi, Helena ; Drenjančević, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Vascular Research 52(suppl 1):1-88 / Rossi, Marco ; Koller, Akos ; Dulak, Jozef - : Karger Publishers, 2015, 72-72

Skup
Joint Meeting of the European Society of Microcirculation (ESM) and European Vascular Biology Organisation (EVBO) 2015

Mjesto i datum
Pisa, Italija, 03.06.2015. - 06.06.2015

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acute exercise ; microcirculation ; endothelim ; laser Doppler flowmetry

Sažetak
Aim: We previously reported impaired microvascular reactivity in athletes after single exposure to exhausting training. The aim of this study was to test if endothelial dysfunction underlies this microvascular impairment. Methods: 9 young trained athletes participated in this study. Blood pressure, heart rate, body mass index (BMI), fasting lipid panel, plasma glucose and C reactive protein (CRP) were measured in all subjects. They all underwent a single progressive rowing training to maximal exhaustion (AE). Blood lactate levels, arterial blood gas analysis and acid base status were measured before and after AE. Cutaneous microvascular blood flow measurements were done by Laser Doppler Flowmetry in response to vascular occlusion (post occlusive reactive hyperemia-PORH) and in response to iontophoresis of acetylcholine (ACh) (endothelium dependent vasodilation) before and after AE. Results: All subjects were normotensive, lean, age- matched males, with normal lipidogram, glucose and CRP blood levels. Serum lactate significantly increased and metabolic acidosis occurred after AE. Systolic blood pressure and heart rate significantly increased during AE. AE caused significant impairment in both microvascular reactivity (PORH) and in ACh induced dilation. Conclusions: The results of this study confirmed that exposure to AE affects microvascular reactivity in young healthy athletes, which is endothelium-dependent.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA