Naslov
Treatment of hyperuricemia with allopurinol in resistant hypertensive predialysis chronic kidney disease patients have additional positive effects on blood pressure and renal function

Autori
Prkačin, Ingrid ; Bulum, Tomislav ; Dražić, Petra ; Boras, Iva ; Vrhovec, Borna ; Legović, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Nephrology Dialysis Transplantation 2015 ; 30 (Suppl. 3): iii94-iii94 / - , 2015

Skup
52nd ERA-EDTA Congress

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 28.05.2015. - 31.05.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
allopurinol; predialysis chronic kidney disease patients; resistant hypertension

Sažetak
Elevated levels of serum uric acid (SUA) have been associated with an increased risk of cardiovascular disease (CVD). Small studies have observed an antihypertensive effect of urate- lowering therapy with Allopurinol (A) in hyperuricemic patients and in obese adolescent males with hypertension. The aim of this study was to investigate effects of A therapy on blood pressure (BP) and renal function parameters in predialysis chronic kidney disease patients (CKDND) with resistant hypertension (RHp). A total of 50 RHp patients with CKDND were divided in two groups: 25 RHp who had BP readings taken before and after being prescribed A for 6 weeks (Group 1) and 25 RHp who had not taken A (Group 2. Treatment with A (Group 1) caused an additional significant reduction in clinic BP: systolic BP fell 9.8 mmHg, diastolic fell 8.0 mmHg, compared with Group 2. There was a reduction of BP that was not related to the primary uric acid level or to other drugs the patients were taking. The results of our study suggest that therapy with A in dose 200 mg daily lowered BP in RHp with CKDND without worsening of kidney function. Blocking the xanthine oxidase- mediated conversion of molecular oxygen to produce mediators of oxidative stres can partially explane additional BP lowering and safety of A in RHp with CKDND.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA