Naslov
HEMATOLOGICAL PROFILE OF NEONATAL HEMOLYTIC JAUNDICE

Autori
Papazovska Cherepnalkovski, Anet ; Piperkova, Katica ; Palčevska Kočevska, Snežana ; Najdanovska Aluloska, Nataša ; Zdravevska, Nikolina ; Gruev, Todor ; Krželj, Vjekoslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
4th International Congress of UENPS / Fani, Anatolitou - Atena : UENPS, 2014, P99-P99

Skup
4th International Congress of UENPS

Mjesto i datum
Atena, Grčka, 11.12.2014. - 14.12.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
neonatal hyperbilirubinemia; hemolysis

Sažetak
Background and aims: Neonatal jaundice is a common pathology requiring immediate detection and management. Clinical challenge is to differentiate between the majority of infants with physiological jaundice and those with pathological causes, thus to establish appropriate management plan. Certain diagnostic tests such as hemoglobin and hematocrit levels, erythrocyte and reticulocyte counts, and blood grouping might hasten the diagnosis. Purpose of the study was to analyze the hematological profile of neonatal hemolytic jaundice due to ABO and Rh incompatibility and compare it to other etiologies of indirect hyperbilirubinemia. Methods: The study group included 284 patients admitted for treatment of jaundice at the University Pediatric Clinic’s Neonatology Department. Results: Most prevalent was jaundice of undefined etiology 44.37%, followed by neonatal infection, prematurity, hemolysis (ABO and Rh incompatibility), and birth trauma. Post –hoc analysis showed statistically significantly lower Hb values in hemolytic jaundice compared to jaundice due neonatal infection (p=0.01). Er and Htc levels were statistically significantly lower for hemolysis compared to undefined etiology and infection. The peak bilirubin level (±SD) in hemolytic jaundice of 379.8±133.6 was statistically significantly higher than the other groups of causes. The analyzed groups significantly differ by to the day bilirubin reaches peak (Tukey HSD test). Conclusions: Hyperbilirubinemia is a frequent neonatal morbidity ; the leading cause being jaundice of undefined etiology. Approximately 15% cases are of hemolytic origin and carry a significant risk for early and severe hyperbilirubinemia. Hematological parameters together with blood grouping are simple diagnostic methods that assist the etiological diagnosis of neonatal hyperbilirubinemia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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