Naslov
In vitro skin models as a tool in optimization of drug formulation

Autori
Eide Flaten, Gøril ; Palac, Zora ; Engesland, André ; Filipović- Grčić, Jelena ; Vanić, Željka ; Škalko-Basnet, Nataša

Izvornik
European journal of pharmaceutical sciences (0928-0987) 75 (2015); 10-24

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
In vitro permeation models; human skin; animal skin; topical formulations; skin therapy
(In vitro permeation models; human skin; animal skin; tTopical formulations; skin therapy)

Sažetak
(Trans)dermal drug therapy is gaining increasing importance in the modern drug development. To fully utilize the potential of this route, it is important to optimize the delivery of active ingredient/drug into/through the skin. The optimal carrier/vehicle can enhance the desired outcome of the therapy therefore the optimization of skin formulations is often included in the early stages of the product development. A rational approach in designing and optimizing skin formulations requires well-defined skin models, able to identify and evaluate the intrinsic properties of the formulation. Most of the current optimization relies on the use of suitable ex vivo animal/human models. However, increasing restrictions in use and handling of animals and human skin stimulated the search for suitable artificial skin models. This review attempts to provide an unbiased overview of the most commonly used models, with emphasis on their limitations and advantages. The choice of the most applicable in vitro model for the particular purpose should be based on the interplay between the availability, easiness of the use, cost and the respective limitations.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

Napomena
S.I.: Drug Delivery for Specific Populations.

POVEZANOST RADA