Naslov
Tryptophan content in serum and brain of long-term insulin-treated diabetic rats

Autori
Jamnicky, Blanka ; Slijepčević, Milivoj ; Hadžija, Mirko ; Juretić, Dubravka ; Borčić, Olga

Izvornik
Acta diabetologica (0940-5429) 28 (1991), 1; 11-18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alloxan diabetes ; amino acid ; Insulin ; Tryptophan

Sažetak
The metabolism of tryptophan (TRP) was studied in diabetic and insulin-treated diabetic rats throughout a five-month period. In alloxan diabetic rats the serum and brain TRP levels were decreased (serum: 38 to 48 mmol/l, brain: 8.6 to 9.2 mmol/g) in comparison to the values of control rats (serum: 59 to 64 mmol/l, brain: 11.3 to 12.6 mmol/g). Daily long-term (for 45, 75, 90 or 135 days) treatment with intermediatly acting insulin (4 IU/rat, s.c.) was not able to restore brain concentration of TRP. On the contrary, the serum TRP concentrations were totally or partially restored. The concentrations of branched chain amino acids (BCAA) were increased in serum (valine=361.2 to 461.0 μmol/l or leucine + isoleucine=431.0 to 520.3 μmol/l) through-out the entire five-month examination period. Insulin treatment did not return serum concentration of BCAA to normal level in the observation period either.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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