Naslov
N-1 i C-5 supstituirani citozinski i uracilni i C-6 supstituirani pirolo[2, 3-d]pirimidinski derivati: sinteza i biološka ispitivanja
(N-1 and C-5 substituted cytosine, uracil and C-6 substituted pyrrolo[2, 3-d]pyrimidine derivatives: synthesis and biological evaluation)

Autori
Stipković Babić, Maja ; Ratković, Ana ; Mihovilović, Moris ; Miošić, Mande ; Kurajica, Livia ; Blažeković, Filip ; Jukić, Marijana ; Glavaš-Obrovac, Ljubica ; Raić-Malić, Silvana ; Gazivoda Kraljević, Tatjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka/ XXIV. Hrvatski skup kemičara i kemijskih inženjera / Ukić, Šime ; Bolanča, Tomislav - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2015, 130-130

ISBN
978-953-6894-54-3

Skup
XXIV. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 21.04.2015. - 24.04.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Citozin; uracil; pirolo[2; 3-d]pirimidin; citostatska ispitivanja
(Cytosine; uracil; pyrrolo[2; 3-d]pyrimidine; cytostatic evaluation)

Sažetak
N-alkylated pyrimidine and pyrrolo[2, 3-d]pyrimidine derivatives have a great role in modern medicine and have shown rather marked antitumor and antiviral activities. The novel N-1 substituted and C-5 alkynylated N4-benzoylcytosine and uracil derivatives have been synthesized by N-alkylation of pyrimidine bases and subsequent Pd-catalysed Sonogashira cross-coupling reaction. N-1 triazolyl derivatives were afforded via 'click' reaction, while pyrrolo[2, 3-d]pyrimidine derivatives were prepared by in situ N-heteroannulation of C-5 alkynylated derivatives. The novel compounds were evaluated against HeLa, CaCo-2, Raji and K562 tumor cell lines.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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