Naslov
1, 2, 3-Triazolni derivati L-asorbinske kiseline i njihova antioksidativna svojstva
(1, 2, 3-Triazole appended L-asorbic acid with antioxidant properties)

Autori
Cazin, Ines ; Kovačić, Ivana ; Meščić, Andrijana ; Stepanić, Višnja ; Raić-Malić, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

ISBN
978-953-6894-54-3

Skup
XXIV. hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 21.04.2015. - 24.04.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
L-askorbinska kiselina ; 1 ; 2 ; 3-triazol ; hvatač radikala ; antitumorski agens
(L-ascorbic acid ; 123-triazole ; radical scavenging ; antitumoral agent)

Sažetak
1, 2, 3-Triazoles have attracted considerable attention in recent years because of their wide range of biological activities against various viruses, malignant cells, microorganisms and their inhibitory activities against several enzymes [1]. Furthermore, since the discovery of vitamin C, the number of its known biological functions is continually expanding. Various pyrimidines and purines containing L- ascorbic acid exhibited significant antiproliferative effects against malignant human tumour cell lines []. Vitamin C is an electron donor, and this property accounts for all its known functions. As an electron donor, vitamin C is a potent water-soluble antioxidant in humans. A series of 1, 4-substituted 1, 2, 3-triazole derivatives of L-ascorbic acid have been synthesized as nucleoside mimetics in which the 1, 2, 3-triazole motif acts as a nucleobase surrogate while L-ascorbic acid mimics the sugar. Antitumor activity of the aforementioned compounds and the influence of the substituent R at the C-4 of the triazole ring on the radical scavenging capacity will be examined.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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