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Pregled bibliografske jedinice broj: 759854

Integrative Analysis of 111 Reference Human Epigenomes

(Roadmap Epigenomics Consortium) Kundaje, Anshul; Meuleman, Wouter; Ernst, Jason; Bilenky, Misha; Yen, Angela; Heravi-Moussavi, Alireza; Kheradpour, Pouya; Zhang, Zhizhuo; Wang, Jianrong; Ziller, Michael J. et al.
Integrative Analysis of 111 Reference Human Epigenomes // Nature, 518 (2015), 7539; 317-330 doi:10.1038/nature14248 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 759854 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Integrative Analysis of 111 Reference Human Epigenomes

Autori
Kundaje, Anshul ; Meuleman, Wouter ; Ernst, Jason ; Bilenky, Misha ; Yen, Angela ; Heravi-Moussavi, Alireza ; Kheradpour, Pouya ; Zhang, Zhizhuo ; Wang, Jianrong ; Ziller, Michael J. ; Amin, Viren ; Whitaker, John W ; Schultz, Matthew D ; Ward, Lucas D. ; Sarkar, Abhishek ; Quon, Gerald ; Sandstrom, Richard S. ; Eaton, Matthew L. ; Wu, Yi-Chieh ; Pfenning, Andreas R. ; Wang, Xinchen ; Claussnitzer, Melina ; Liu, Yaping ; Coarfa, Cristian R. ; Harris, Alan ; Shoresh, Noam ; Epstein, Charles B. ; Gjoneska, Elizabeta ; Leung, Danny ; Xie, Wei ; Hawkins, David R. ; Lister, Ryan ; Hong, Chibo ; Gascard, Philippe ; Mungall, Andrew J. ; Moore, Richard ; Chuah, Eric ; Tam, Angela ; Canfield, Theresa K. ; Hansen, R Scott ; Kaul, Rajinder ; Sabo, Peter J. ; Bansal, Mukul S. ; Carles, Annaick ; Dixon, Jesse R. ; Farh, Kai-How ; Feizi, Soheil ; Karlić, Rosa ; Kim, Ah-Ram ; Kulkarni, Ashwinikumar ; Li, Daofeng ; Lowdon, Rebecca ; Elliott, GiNell ; Mercer, Tim R. ; Neph, Shane J. ; Onuchic, Vitor ; Polak, Paz ; Rajagopal, Nisha ; Ray, Pradipta ; Sallari, Richard C. ; Siebenthall, Kyle T. ; Sinnott-Armstrong, Nicholas A. ; Stevens, Michael ; Thurman, Robert E. ; Wu, Jie ; Zhang, Bo ; Zhou, Xin ; Beaudet, Arthur E. ; Boyer, Laurie A. ; De Jager, Philip L. ; Farnham, Peggy J. ; Fisher, Susan J. ; Haussler, David ; Jones, Steven J.M. ; Li, Wei ; Marra, Marco A. ; McManus, Michael T. ; Sunyaev, Shamil ; Thomson, James A. ; Tlsty, Thea D. ; Tsai, Li-Huei ; Wang, Wei ; Waterland, Robert A. ; Zhang, Michael Q. ; Chadwick, Lisa H. ; Bernstein, Bradley E. ; Costello, Joseph F. ; Ecker, Joseph R. ; Hirst, Martin ; Meissner, Alexander ; Milosavljević, Aleksandar ; Ren, Bing ; Stamatoyannopoulos, John A. ; Wang, Ting ; Kellis, Manolis

Kolaboracija
Roadmap Epigenomics Consortium

Izvornik
Nature (0028-0836) 518 (2015), 7539; 317-330

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
RNA ; chromatin ; DNA ; histone ; epigenome ; tissue specificity

Sažetak
The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for primary cells and tissues. Here we describe the integrative analysis of 111 reference human epigenomes generated as part of the programme, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression. We establish global maps of regulatory elements, define regulatory modules of coordinated activity, and their likely activators and repressors. We show that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Our results demonstrate the central role of epigenomic information for understanding gene regulation, cellular differentiation and human disease.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Računarstvo



POVEZANOST RADA

Projekti:
MZOS-119-0982913-1211 - Računalna genomika mikrobnih okoliša i bioinformatika ekstremofila (Vlahoviček, Kristian, MZOS ) ( CroRIS)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Rosa Karlić (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

(Roadmap Epigenomics Consortium) Kundaje, Anshul; Meuleman, Wouter; Ernst, Jason; Bilenky, Misha; Yen, Angela; Heravi-Moussavi, Alireza; Kheradpour, Pouya; Zhang, Zhizhuo; Wang, Jianrong; Ziller, Michael J. et al.
Integrative Analysis of 111 Reference Human Epigenomes // Nature, 518 (2015), 7539; 317-330 doi:10.1038/nature14248 (međunarodna recenzija, članak, znanstveni)
(Roadmap Epigenomics Consortium) (Roadmap Epigenomics Consortium) Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J. & Ziller, M. (2015) Integrative Analysis of 111 Reference Human Epigenomes. Nature, 518 (7539), 317-330 doi:10.1038/nature14248.
@article{article, author = {Kundaje, Anshul and Meuleman, Wouter and Ernst, Jason and Bilenky, Misha and Yen, Angela and Heravi-Moussavi, Alireza and Kheradpour, Pouya and Zhang, Zhizhuo and Wang, Jianrong and Ziller, Michael J. and Amin, Viren and Whitaker, John W and Schultz, Matthew D and Ward, Lucas D. and Sarkar, Abhishek and Quon, Gerald and Sandstrom, Richard S. and Eaton, Matthew L. and Wu, Yi-Chieh and Pfenning, Andreas R. and Wang, Xinchen and Claussnitzer, Melina and Liu, Yaping and Coarfa, Cristian R. and Harris, Alan and Shoresh, Noam and Epstein, Charles B. and Gjoneska, Elizabeta and Leung, Danny and Xie, Wei and Hawkins, David R. and Lister, Ryan and Hong, Chibo and Gascard, Philippe and Mungall, Andrew J. and Moore, Richard and Chuah, Eric and Tam, Angela and Canfield, Theresa K. and Hansen, R Scott and Kaul, Rajinder and Sabo, Peter J. and Bansal, Mukul S. and Carles, Annaick and Dixon, Jesse R. and Farh, Kai-How and Feizi, Soheil and Karli\'{c}, Rosa and Kim, Ah-Ram and Kulkarni, Ashwinikumar and Li, Daofeng and Lowdon, Rebecca and Elliott, GiNell and Mercer, Tim R. and Neph, Shane J. and Onuchic, Vitor and Polak, Paz and Rajagopal, Nisha and Ray, Pradipta and Sallari, Richard C. and Siebenthall, Kyle T. and Sinnott-Armstrong, Nicholas A. and Stevens, Michael and Thurman, Robert E. and Wu, Jie and Zhang, Bo and Zhou, Xin and Beaudet, Arthur E. and Boyer, Laurie A. and De Jager, Philip L. and Farnham, Peggy J. and Fisher, Susan J. and Haussler, David and Jones, Steven J.M. and Li, Wei and Marra, Marco A. and McManus, Michael T. and Sunyaev, Shamil and Thomson, James A. and Tlsty, Thea D. and Tsai, Li-Huei and Wang, Wei and Waterland, Robert A. and Zhang, Michael Q. and Chadwick, Lisa H. and Bernstein, Bradley E. and Costello, Joseph F. and Ecker, Joseph R. and Hirst, Martin and Meissner, Alexander and Milosavljevi\'{c}, Aleksandar and Ren, Bing and Stamatoyannopoulos, John A. and Wang, Ting and Kellis, Manolis}, year = {2015}, pages = {317-330}, DOI = {10.1038/nature14248}, keywords = {RNA, chromatin, DNA, histone, epigenome, tissue specificity}, journal = {Nature}, doi = {10.1038/nature14248}, volume = {518}, number = {7539}, issn = {0028-0836}, title = {Integrative Analysis of 111 Reference Human Epigenomes}, keyword = {RNA, chromatin, DNA, histone, epigenome, tissue specificity} }
@article{article, author = {Kundaje, Anshul and Meuleman, Wouter and Ernst, Jason and Bilenky, Misha and Yen, Angela and Heravi-Moussavi, Alireza and Kheradpour, Pouya and Zhang, Zhizhuo and Wang, Jianrong and Ziller, Michael J. and Amin, Viren and Whitaker, John W and Schultz, Matthew D and Ward, Lucas D. and Sarkar, Abhishek and Quon, Gerald and Sandstrom, Richard S. and Eaton, Matthew L. and Wu, Yi-Chieh and Pfenning, Andreas R. and Wang, Xinchen and Claussnitzer, Melina and Liu, Yaping and Coarfa, Cristian R. and Harris, Alan and Shoresh, Noam and Epstein, Charles B. and Gjoneska, Elizabeta and Leung, Danny and Xie, Wei and Hawkins, David R. and Lister, Ryan and Hong, Chibo and Gascard, Philippe and Mungall, Andrew J. and Moore, Richard and Chuah, Eric and Tam, Angela and Canfield, Theresa K. and Hansen, R Scott and Kaul, Rajinder and Sabo, Peter J. and Bansal, Mukul S. and Carles, Annaick and Dixon, Jesse R. and Farh, Kai-How and Feizi, Soheil and Karli\'{c}, Rosa and Kim, Ah-Ram and Kulkarni, Ashwinikumar and Li, Daofeng and Lowdon, Rebecca and Elliott, GiNell and Mercer, Tim R. and Neph, Shane J. and Onuchic, Vitor and Polak, Paz and Rajagopal, Nisha and Ray, Pradipta and Sallari, Richard C. and Siebenthall, Kyle T. and Sinnott-Armstrong, Nicholas A. and Stevens, Michael and Thurman, Robert E. and Wu, Jie and Zhang, Bo and Zhou, Xin and Beaudet, Arthur E. and Boyer, Laurie A. and De Jager, Philip L. and Farnham, Peggy J. and Fisher, Susan J. and Haussler, David and Jones, Steven J.M. and Li, Wei and Marra, Marco A. and McManus, Michael T. and Sunyaev, Shamil and Thomson, James A. and Tlsty, Thea D. and Tsai, Li-Huei and Wang, Wei and Waterland, Robert A. and Zhang, Michael Q. and Chadwick, Lisa H. and Bernstein, Bradley E. and Costello, Joseph F. and Ecker, Joseph R. and Hirst, Martin and Meissner, Alexander and Milosavljevi\'{c}, Aleksandar and Ren, Bing and Stamatoyannopoulos, John A. and Wang, Ting and Kellis, Manolis}, year = {2015}, pages = {317-330}, DOI = {10.1038/nature14248}, keywords = {RNA, chromatin, DNA, histone, epigenome, tissue specificity}, journal = {Nature}, doi = {10.1038/nature14248}, volume = {518}, number = {7539}, issn = {0028-0836}, title = {Integrative Analysis of 111 Reference Human Epigenomes}, keyword = {RNA, chromatin, DNA, histone, epigenome, tissue specificity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • MEDLINE
  • Nature Index

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