Naslov
In-line monitoring of API synthesis and product characterisation

Autori
Jednačak, Tomislav ; Novak, Predrag ; Meštrović, Ernest ; Šahnić, Damir ; Parlov Vuković, Jelena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
24. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka / Ukić, Šime ; Bolanča, Tomislav - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2015, 101-101

ISBN
978-953-6894-54-3

Skup
24. hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 21.04.2015. - 24.04.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
in-line Raman spectroscopy ; API synthesis ; product identification ; NMR spectroscopy

Sažetak
In recent years, process analytical technology (PAT) has emerged as one of the key elements to fully implement in-line analytical techniques for process monitoring. In-line techniques based on vibrational spectroscopy enable in situ monitoring of physical and chemical transformations and provide insight into the mixture composition at a given time. Here we report on using in-line Raman spectroscopy for monitoring the synthesis of an active pharmaceutical ingredient (API) shown in Figure 1. This API is used as a selective proton pump inhibitor. Raman spectroscopy was employed for the remote detection through a fibre optic probe which facilitated real-time monitoring of the API synthesis. In order to unambiguously identify the reaction product, the obtained crystals were further evaluated off-line using NMR spectroscopy in solution and solid state.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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