Naslov
THE IMPACT OF HEPATITIS C VIRAL INFECTION ON RENAL GRAFT AND PATIENT’S SURVIVAL – A SINGLE CENTER EXPERIENCE

Autori
Anić, Kata ; Mikolašević, Ivana ; Orlić, Lidija ; Devčić, Bosiljka ; Jakopčić, Ivan ; Rački, Sanjin

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka ; 4th Congress of Nephrology of Bosnia and Herzegovina with international participation / Enisa Mesić - , 2015, 90-90

Skup
4th Congress of Nephrology of Bosnia and Herzegovina with international participation

Mjesto i datum
Sarajevo, Bosna i Hercegovina, 22.04.2015. - 25.04.2015

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hepatitis C; transplantacija
(hepatitis C; transplantation)

Sažetak
INTRODUCTION: It remains controversial whether hepatitis C infection (HCV) alters log-term patients and renal graft survival. Our aim was to analyze the effects of HCV infection on patients and graft survival. METHODS: We retrospectively examined the 23-year (1990-2013) data of 471 renal transplant recipients (RTRs) mean age 50.2±14 years who were anti-HCV negative and 21 RTRs mean age 49±8 years who were anti-HCV positive at the time of transplantation. We compared graft and patients survival rates and causes of death and graft failure in HCV-positive and HCV-negative RTRs. RESULTS: There was no statistically significant difference between the two groups related to age or gender and due to the duration of dialysis treatment before the transplantation The mean posttransplant follow-up of 471 HCV negative RTRs was 61.1±59.3 months and for 21 HCV positive RTRs was 75.3±44.3 months (p=NS).There was no significant difference due to acute rejection crisis during the first-year of follow up (p=NS). The mean values of serum creatinine didn’t showed any significant differences after one-year, two-years and five-years of follow-up between the HCV negative RTRs and HCV positive RTRs (p=NS). In the HCV positive RTRs the main reason for graft loss was a chronic allograft nephropathy (CAN) (42.9%) and acute rejection crisis (42.9%). On the other hand, CAN was the cause of graft loss in the 44.1% of HCV negative RTRs, while acute rejection was the cause of graft loss in the 22% of RTRs that were anti-HCV negative. There were no significant differences in the patients survival between the HCV positive RTRs and HCV negative groups of our renal transplant recipients (38.1% vs. 22.9% ; p=NS). CONCLUSION: According to our experience, patients and graft survival were not affected by HCV infection. Anti-HCV positively should not preclude chronic renal failure patients from renal transplantation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA