Naslov
The involvement of alpha2-adrenoceptors in the anticonvulsive effect of swim stress in mice

Autori
Peričić, Danka ; Švob, Dubravka ; Jazvinšćak Jembrek, Maja ; Mirković Kos, Kety

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Fundamental and Clinical Pharmacology, vol.15, Suppl.1 / Bousquet, Pascal - Strasbourg : Blackwell Publishing, 2001

Skup
Third meeting of the Federation of European Pharmacological Societies (EPHAR)

Mjesto i datum
Lyon, Francuska, 06.07.2001. - 09.07.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
swim stress; picrotoxin-induced convulsions; alpha2-adrenoceptors

Sažetak
Objective: The aim of this study was to explore the possible involvement of alpha2-adrenoceptors in the previously observed anticonvulsive effect of swim stress in mice. Design and Methods: The mice were, prior to exposure to swim stress and the i.v. infusion of picrotoxin, pre-treated with clonidine (a preferential alpha2-adrenoceptor agonist), yohimbine and idazoxan (a nonselective and a selective alpha2-adrenoceptor antagonist), or niguldipine (an alpha1-adrenoceptor antagonist), and the latency to the onset of two convulsant signs and death was registered. Results: In control unstressed animals yohimbine (2 mg/kg i.p.) shortened the latency, i.e. it lowered the dose of picrotoxin needed to produce death, and niguldipine (5 mg/kg i.p.) enhanced the doses of picrotoxin needed to produce running/bouncing clonus, tonic hindlimb extension and death. In swim stressed animals clonidine (0.1 and 1 mg/kg) enhanced, while idazoxan (1 mg/kg) decreased doses of picrotoxin producing two convulsive signs and death. Yohimbine decreased in stressed animals the doses of convulsant producing tonic hindlimb extension and death. Niguldipine enhanced in stressed animals doses of picrotoxin producing all symptoms. The results demonstrate the alpha2-adrenoceptor agonist - induced potentiation and alpha2-adrenoceptor antagonists- induced diminution of the anticonvulsive effect of stress. Additionally, they show the anticonvulsive effect of niguldipine in unstressed and stressed animals. Conclusions: The results suggest that alpha2- adrenoceptors are involved in the anticonvulsive effect of swim stress in mice.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA