Naslov
The effects of paroxetine or tianeptine on peripheral serotonergic measures in depressed patients

Autori
Pivac, Nela ; Muck-Šeler, Dorotea ; Jakovljević, Miro ; Šagud, Marina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Third Croatian Congress of Pharmacology with International Participation : abstracts ; u: Periodicum Biologorum. Supplement 103 (2001) / Vitale, Branko - Zagreb : IGP, 2001, 115-115

Skup
Croatian Congress of Pharmacology with International Participation (3 ; 2001)

Mjesto i datum
Zagreb, Hrvatska, 18.09.2001. - 21.09.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
paroxetine; tianeptine; platelet serotonin; platelet MAO

Sažetak
It is widely accepted that serotonin (5-HT) plays a role in the pathophysiology and treatment of major depression. The data on the role of 5-HT have been obtained using blood platelets as a peripheral model for the central serotonergic synaptosomes. Recent reports suggested that platelet 5-HT concentration and monoamine oxidase (MAO) activity might serve as biological, even trait markers for particular mental disturbances. The present study investigated the effects of two antidepressants, with completely opposite effects on serotonergic system (tianeptine, a drug that stimulates 5-HT reuptake, and paroxetine, a selective 5-HT reuptake inhibitor), on clinical outcome and on peripheral 5-HT markers in depressed patients. The aim of the study was to determine the effects of tianeptine or paroxetine on platelet 5-HT concentration and platelet MAO activity in depressed patients, and to compare platelet 5-HT concentration and platelet MAO activity in responders and nonresponders to tianeptine or paroxetine with the values in sex-matched controls. The study included 61 female subjects: 36 nonpsychotic, nonsuicidal, depressed patients who scored 26.05 ą 2.48 or 27.07 ą 2.41 at Hamilton Depression Rating Scale (HDRS) before treatment with tianeptine (N=21) or paroxetine (N=15). Control group comprised of 25 sex-matched drug-free healthy subjects. The treatment response was determined according to the 50% fall in HDRS after 5-6 weeks of antidepressant treatment. All data, expressed as means ą SD, were evaluated using one-way analysis of variance followed by Tukey multiple comparison procedure. There were 10 responders and 11 nonresponders in tianeptine, and 7 responders and 8 nonresponders in paroxetine treated groups. Tianeptine treatment did not alter (F=1.5 ; df=4, 62 ; p=0.21) platelet 5-HT concentration in healthy subjects and in depressed patients subdivided into responders and nonresponders. Platelet 5-HT concentration was significantly different between healthy controls and patients trated with paroxetine (F=11.4 ; df=4, 50 ; p<0.001), with decreased (p<0.05) platelet 5-HT concentration in responders and nonresponders. At baseline (before treatment) nonresponders to paroxetine had significantly higher (p<0.05) platelet 5-HT concentration than responders. Platelet MAO activity was not significantly different between healthy controls and patients subdivided according to the treatment response to paroxetine (F=0.40 ; df=4.50 ; p=0.80), or tianeptine (F=0.60 ; df=4, 62 ; p=0.60). Conclusion: Our results show that treatment with paroxetine, but not with tianeptine, significantly affected platelet 5-HT concentration in depressed patients. Lower pre-treatment platelet 5-HT concentration might predict therapeutic outcome to paroxetine, but not to tianeptine. Paroxetine treatment decreased significantly platelet 5-HT concentrations in both responders and nonresponders. Platelet MAO activity was not associated with a treatment response to tianeptine or paroxetine in depressed patients. Our data indicate that platelet 5-HT concentration, but not platelet MAO activity, might be used as one of the biological markers to predict therapeutic outcome to paroxetine.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA