Naslov
Platelet 5-HT concentration in PTSD

Autori
Šagud, Marina ; Jakovljević, Miro ; Pivac, Nela ; Muck-Šeler, Dorotea ; Mihaljević-Peleš, Alma

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Americal Psychiatric Association 2001 Annual meeting : Abstracts / - , 2001, NR649-NR649

Skup
American Psychiatric Association 2001 Annual meeting

Mjesto i datum
New Orleans (LA), Sjedinjene Američke Države, 05.05.2001. - 10.05.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
platelet serotonin; PTSD

Sažetak
Posttraumatic stress disorder (PTSD) is associated with alterations in various neurobiological systems, including serotonergic. The present study included male subjects: 48 war veterans with combat related PTSD, 48 age-matched healthy controls, 48 nonpsychotic depressed patients, 14 war veterans without PTSD, and 25 war veterans with PTSD who were prisoners of war (POWs), and focused on platelet serotonin (5-HT) concentration in PTSD subject and its relationship with different clusters of depressive symptoms. There was a significant difference (F=3.63, df=4, 178 ; p<0.007) in platelet 5-HT concentration between these groups, with higher (p<0.05) platelet 5-HT in PTSD subjects and POWs than in depressed patients. Platelet 5-HT concentrations was significantly different in PTSD subjects with severe loss of appetite (F=3.65 ; df=3, 76 ; p=0.016), weight loss (F=3.45 ; df=3, 76 ; p=0.021), and exposed to additional severe acute stress (F=3.53 ; df=3, 78 ; p=0.019), when compared to control subjects, but did not differ significantly in PTSD subjects divided by the occurrence of other particular symptoms, i.e. pain and depressive syndrome, insomnia, panic attacs, anxiety, aggressiveness, and suicidality, as determined by 21-item Hamilton Rating Scale for Depression. These results show that war veterans and POWs with PTSD have higher platelet 5-HT concentration, and that platelet 5-HT contentration was increased in PTSD subjects with severe symptoms of appetite and weight loss and exposed to additional stress. Our findings suggest that platelet 5-HT might indicate the severity of depressive symptoms that occur in PTSD, or that some of these symptoms are linked to the alterations in 5-HT function.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA