Naslov
Platelet 5-HT concentration and comorbid depression in war veterans with or without posttraumatic stress disorder

Autori
Muck-Šeler, Dorotea ; Pivac, Nela ; Jakovljević, Miro ; Šagud , Marina ; Mihaljević-Peleš, Alma

Izvornik
Journal of affective disorders (0165-0327) 75 (2003), 2; 171-179

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Posttraumatic stres disorder; war veterans; depression; platelet 5-HT;

Sažetak
Background: The serotonergic system is implicated in the pathophysiology of posttraumatic stress disorder (PTSD) and depression. The present study focused on platelet serotonin (5-HT) concentration and symptoms of comorbid depression in war veterans with or without PTSD. Methods: PTSD and depression were evaluated using Clinician Administered PTSD Scale, Davidson Trauma Scale, Montgomery Asberg Depression Rating Scale and Hamilton Anxiety Scale. Sixty five male drug-free war veterans (48 with PTSD and 17 without PTSD) and 65 age- and sex-matched healthy controls were studied. Results: Comorbid depression occurred in 54% and 31% of war veterans with PTSD and without PTSD, respectively. Platelet 5-HT concentration was similar in the groups of depressed and nondepressed war veterans with or without PTSD and healthy controls. Platelet 5-HT concentration was found to differ between war veterans with various degrees of appetite loss. A positive correlation was observed between platelet 5-HT concentration and severity of appetite loss in veterans with PTSD. There was no relationship between platelet 5-HT concentration and severity of other symptoms of PTSD or depression. Limitations: War veterans included in the study were outpatients. Conclusions: War veterans with PTSD had a high incidence of comorbid depression, that was not related to platelet 5-HT concentration. The marked relationship between platelet 5-HT concentration and severity of appetite loss, suggested that 5-HT system is involved in the regulation of appetite, at least in depressed war veterans with PTSD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA