Naslov
Radioprotective effects of synthetised adamantyl-thienylcyclidines

Autori
Ferle-Vidović, Ana ; Jukić, Ivan ; Škare, Danko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
IRPA Regional Congress on Radiation Protection in Central Europe: Radiation protection and health - Book of Abstracts / Obelić, B. ; Ranogajec-Komor, M. ; Miljanić, S. ; Krajcar Bronić - Zagreb : Croatian Radiation Protection Association, 2001

Skup
IRPA Regional Congress on Radiation Protection in Central Europe: Radiation protection and health

Mjesto i datum
Dubrovnik, Hrvatska, 20.05.2001. - 25.05.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
xx

Sažetak
Several adamantyl derivatives of thienylcyclidine 1-(1(2-thyenylcyclohexyl)) piperidine (TCP), were sythetised and characterised (Ad-TCP I-IV). Their biological activity was evaluated by in vitro testing of their effect on proliferative and reproductive ability of human tumor strain and non-malignant mouse fobroblasts in culture. These effect were compared with those of thyenylcyclidine (TCP). We also tested them on cultured cells, for their radioprotective effect after ionising irradiation. The results with non-malignant mouse fibroblasts and human tumour cells, show that the piperidine derivative of adamantyl-thienylcyclidine (Ad-TCP II) has rather outstanding radioprotective properties. This derivative revealed significant radioprotection at all survival levels, depending on the malignant or non-malignant origin of the cells, and it was significantly more evident on mouse fibroblasts then on human tumor cells. These effect were compared with those of thienylciycidine.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA