Naslov
Kinesin-8 Motors Improve Nuclear Centering by Promoting Microtubule Catastrophe

Autori
Glunčić, Matko ; Maghelli, Nicola ; Krull, Alexander ; Krstić, Vladimir ; Ramunno-Johnson, Damien ; Pavin, Nenad ; Tolić, Iva M. ;

Izvornik
Physical Review Letters (0031-9007) 114 (2015); 078103-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
Kinesin-8; Centering; Microtubule

Sažetak
In fission yeast, microtubules push against the cell edge, thereby positioning the nucleus in the cell center. Kinesin-8 motors regulate microtubule catastrophe ; however, their role in nuclear positioning is not known. Here we develop a physical model that describes how kinesin-8 motors affect nuclear centering by promoting a microtubule catastrophe. Our model predicts the improved centering of the nucleus in the presence of motors, which we confirmed experimentally in living cells. The model also predicts a characteristic time for the recentering of a displaced nucleus, which is supported by our experiments where we displaced the nucleus using optical tweezers.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija

POVEZANOST RADA