Naslov
Serotonin and apoptosis: studies on rat lymphocytes

Autori
Štefulj, Jasminka ; Jakopec, Sanjica ; Osmak, Maja ; Jernej, Branimir

Izvornik
Neuroimmunomodulation (1021-7401) 10 (2002), 3; 132-133

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
apoptosis; serotonin; 5HT; lymphocytes; proliferation; rat

Sažetak
Objective: The apoptogenic potential of serotonin (5-hydroxytryptamine, 5HT) on mitogen-stimulated lymphocytes was studied in primary cultures of rat spleen cells, in two sets of experiments. Methods: Apoptosis was measured either by morphological criteria (experiment 1) or by flow cytometry (experiment 2). Results: In both experiments serotonin, in concentration producing half-maximal inhibition of lymphocyte proliferation, has significantly increased basal level of apoptosis. Conclusion: Apoptotic mechanism should be taken into account when considering immunoinhibition induced by serotonin.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA