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Pregled bibliografske jedinice broj: 753379

Increased inflammation and lower platelet 5-HT in depression with metabolic syndrome

Silić, Ante; Karlović, Dalibor; Serretti, Alessandro
Increased inflammation and lower platelet 5-HT in depression with metabolic syndrome // Journal of affective disorders, 141 (2012), 1; 72-78 doi:10.1016/j.jad.2012.02.019 (međunarodna recenzija, članak, znanstveni)

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Naslov
Increased inflammation and lower platelet 5-HT in depression with metabolic syndrome

Autori
Silić, Ante ; Karlović, Dalibor ; Serretti, Alessandro

Izvornik
Journal of affective disorders (0165-0327) 141 (2012), 1; 72-78

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Major depressive disorder; Metabolic syndrome; Interleukin 6; C-reactive protein; Platelet serotonin

Sažetak
Recent studies suggest comorbidity between major depressive disorder (MDD) and metabolic syndrome. For both disorders, impaired serotoninergic neurotransmission and inflammatory factors have been suggested. The objective of this study was to investigate the concentration of platelet serotonin, interleukin-6 (IL-6) and C-reactive protein (CRP) in MDD patients with and without metabolic syndrome. The second goal was to investigate the association of the concentrations of platelet serotonin, IL-6 and CRP with individual components of metabolic syndrome in MDD patients. A total of 145 MDD patients were included in the study (diagnosed according DSM IV TR criteria). The metabolic syndrome was defined according to the criteria of the American National Cholesterol Education Program- Treatment Panel III (ATP III). Inflammation factors (IL-6 and CRP) and platelet serotonin concentration were assessed by the enzyme- linked immunosorbent assay (ELISA). MDD patients with metabolic syndrome showed lower platelet serotonin and higher IL-6 and CRP concentrations when compared to MDD patients without metabolic syndrome. An inverse correlation was found between platelet serotonin and waist circumference and serum glucose levels. A positive correlation was found between IL-6 and glucose or triglyceride concentrations, while the correlation with HDL cholesterol was negative. Data on dietary habits or physical activity prior to hospitalisation were not collected. Also, the study was a cross-sectional without a prospective design. Metabolic syndrome in patients with MDD may be associated with reduced concentrations of platelet serotonin and increased concentrations of IL-6 and CRP.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
KBC "Sestre Milosrdnice",
Psihijatrijska bolnica "Sveti Ivan" Zagreb

Profili:

Avatar Url Ante Silić (autor)

Avatar Url Dalibor Karlović (autor)

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Silić, Ante; Karlović, Dalibor; Serretti, Alessandro
Increased inflammation and lower platelet 5-HT in depression with metabolic syndrome // Journal of affective disorders, 141 (2012), 1; 72-78 doi:10.1016/j.jad.2012.02.019 (međunarodna recenzija, članak, znanstveni)
Silić, A., Karlović, D. & Serretti, A. (2012) Increased inflammation and lower platelet 5-HT in depression with metabolic syndrome. Journal of affective disorders, 141 (1), 72-78 doi:10.1016/j.jad.2012.02.019.
@article{article, author = {Sili\'{c}, Ante and Karlovi\'{c}, Dalibor and Serretti, Alessandro}, year = {2012}, pages = {72-78}, DOI = {10.1016/j.jad.2012.02.019}, keywords = {Major depressive disorder, Metabolic syndrome, Interleukin 6, C-reactive protein, Platelet serotonin}, journal = {Journal of affective disorders}, doi = {10.1016/j.jad.2012.02.019}, volume = {141}, number = {1}, issn = {0165-0327}, title = {Increased inflammation and lower platelet 5-HT in depression with metabolic syndrome}, keyword = {Major depressive disorder, Metabolic syndrome, Interleukin 6, C-reactive protein, Platelet serotonin} }
@article{article, author = {Sili\'{c}, Ante and Karlovi\'{c}, Dalibor and Serretti, Alessandro}, year = {2012}, pages = {72-78}, DOI = {10.1016/j.jad.2012.02.019}, keywords = {Major depressive disorder, Metabolic syndrome, Interleukin 6, C-reactive protein, Platelet serotonin}, journal = {Journal of affective disorders}, doi = {10.1016/j.jad.2012.02.019}, volume = {141}, number = {1}, issn = {0165-0327}, title = {Increased inflammation and lower platelet 5-HT in depression with metabolic syndrome}, keyword = {Major depressive disorder, Metabolic syndrome, Interleukin 6, C-reactive protein, Platelet serotonin} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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