Naslov
Patholoy of L. monocytogenes infection

Autori
Deckert, Martina ; Abram, Maja ; Schluter, Dirk

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proccedings of ISOPOL XIV / Hof, Herbert - Mannheim : Universitatsklinikum, Insti. fur Med. Mikrobiol. unu Hygiene, 2001

Skup
International Symposium on Problems of Listeriosis

Mjesto i datum
Mannheim, Njemačka, 13.05.2001. - 16.05.2001

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
experimental listeriosis; neonatal; cerebral

Sažetak
L. monocytogenes may cause severe infections, particularly in immunocompromised persons including pregnant women, fetuses and neonates as well as in patients with impaired cellular immune responses. Infection during pregnancy may result in severe fetal disease and even abortion. Neonatal listeriosis may manifest as sepsis with involvement of liver, spleen, and CNS. In contrast, listeriosis of adult patients is ususally confined to the CNS. Cerebral listeriosis differs from other bacterial infections of the CNS due to the ability of L. monocytogenes to cause meningitis, encephalitis, brain abscess or combined forms. In order to systematically study the immune responses that play a role in the various forms of human listeriosis we have established animal models of pregnancy-associated and cerebral infection, respectively. Whereas mice normally eliminate L. monocytogenes effectively following either i.v. or i.p. infection, pregnant mice fail to clear the bacteria and instead develop a severe, necrotizing hepatitis. Infection of placenta and fetuses resulted in a high abortion rate due to lack of effector cells in placenta and fetus as well as low levels of anti-listerial cytokines. Cerebral listeriosis of mice closely parallels human CNS infection including the high affinity of bacteria for structures of the ventricular system and the brain stem. Clinically relevant, mice can be protected from the inevitably fatal course of CNS listeriosis by a prior systemic immunization, which results in an accelerated and more extensive recruitment of protective CD4+ and CD8+ T cells to the L. monocytogenes-infected brain as well as in an increased production of protective cytokines. In addition to pro-inflammatory cytokines, the immunosuppressive mediator IL-10 plays a pathogenetically relevant role by the prevention of an hyperinflammatory immune reaction in the CNS. Thus, the various forms of experimental murine listeriosis share important features with human listeriosis and provide a suitable tool to dissect the immune response and to identify pathogenetically relevant factors in order to improve therapeutic strategies and the patients’ prognosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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