Naslov
Placental pathology in pregnant BALB/C mice inoculated with Listeria monocytogenes

Autori
Abram, Maja ; Dorić, Miljenko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Croatian and Slovenian Symposium "Zoonoses today and tomorrow" / Prukner-Radovčić, Estella; Presečki, Vladimir - Zagreb : Hrvatsko mikrobiološko društvo, 2001

Skup
Croatian and Slovenian Symposium on Microbiology and Infectious diseases "Zoonoses today and tomorrow"

Mjesto i datum
NP Plitvička jezera, Hrvatska, 21.06.2001. - 23.06.2001

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Listeria monocytogenes; placenta

Sažetak
Listeria monocytogenes has been recognized as a significant pathogen occuring world-wide and involving a wide range of wild and domestic animals including man. L. monocytogenes causes sepsis and meningoencephalitis in immunocompromised hosts and a devastating maternal/fetal infection during pregnancy. We established an experimental murine model of congenital listeriosis, which demonstrated that pregnancy markedly impaired control of listeria in pregnant animals. In this study, Balb/C mice were intravenouslly inoculated with L. monocytogenes at day 14 of pregnancy, and analyzed for placental infection 1, 2, 3 and 6 post infection (p.i.). We followed the bacterial load, pathohistological and immunohistochemical findings in the placental tissue. At days 2 and 3 p.i., the placenta was characterized by large, hemorrhagic necrosis in association with numerous bacteria which covered the entire organ, while the inflammatory reaction was confined to single Ly-6 G+ granulocytes. Obviously, the immune response at the materno-fetal interface was insufficient to control the bacteria. The placenta and uterus from mice that were analyzed at day 6 i.p., i.e., day 20 of pregnancy did not show any more evidence for infection. Our results stress the necessity of a rapid therapeutic intervention in colonized by L. monocytogenes, protection of the fetus becomes extremely difficult because of the markedly suppressed immune response in the placenta and the immunologically immature fetus, to which immune effector cells are not recruited.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA