Naslov
Reactions Catalyzed by Halohydrin Dehalogenases

Autori
Majerić Elenkov, Maja ; Szymanski, Wiktor ; Janssen Dick B.

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni

Knjiga
Science of Synthesis ; Biocatalysis in Organic Synthesis 2

Urednik/ci
Faber, Kurt ; Fessner, Wolf-Dieter ; Turner, Nicholas

Izdavač
Georg Thieme Verlag

Grad
Stuttgart

Godina
2014

Raspon stranica
507-527

ISBN
978-3-13-174161-5

Ključne riječi
Epoxides, Hydroxynitriles, Microorganisms, Alcohols, Cyanides

Sažetak
In some bacteria, halohydrin dehalogenases catalyze the conversion of vicinal halo alco- hols, such as 1, 3-dichloropropane or 3-chloropropane-1, 2-diol, into epoxides, and thereby play a role in the biodegradation of halogenated organic compounds. In the reverse reaction, i.e. epoxide ring opening, various small anions can replace the halide, allowing the synthesis of β-substituted alcohols, including β-hydroxynitriles and β-azido alcohols. These remarkable catalytic properties have been modified by structure-based protein engineering, making the enzymes suitable for diverse applications.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA