Naslov
Antiproliferative effect and selectivity of sodium dichloro-bis[n-phenyl-5-chloro-salicylideneiminato-n, o]ruthenate(iii) in vitro.

Autori
Kahrović, Emira ; Kraljević Pavelić, Sandra

Izvornik
International journal of pharmacy and pharmaceutical sciences (0975-1491) 7 (2015), 1; 86-88

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antiproliferative effect; Anticancer drugs; Ruthenium; Schiff bases; Selectivity; SW620

Sažetak
Ruthenium complexes attracted special attention in recent decades due to their anticancer properties. Since a number of Ru(III) complexes with Schiff bases showed moderate activity to bind DNA, antiproliferative effect of a chloro-ruthenium(III) complex which contains two O, N-bidentate Schiff bases derived from 5-chloro-salicylaldehyde was tested against cervical carcinoma, pancreatic carcinoma, hepatocellular carcinoma, metastatic lesions of colorectal adenocarcinoma and nontumoral cells WI38. The complex showed moderate antiproliferative properties in vitro and significant selectivity to SW620 metastatic lesions of colon cancer. Based on the positive research on ruthenium-based anticancer drugs and their generally moderate cytotoxicity in vitro (IC50) compared to platinum drugs which are in use, the titled compound might be a candidate for investigation in vivo, particularly to SW620.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA