Naslov
A mouse cytomegalovirus glycoprotein retains MHC class I complexes in the ERGIC/cis-Golgi compartments

Autori
Ziegler, Heike ; Thale, Regine ; Lučin, Pero ; Muranyi, Walter ; Flohr, Thomas ; Hengel, Hartmut ; Farrell, Helen ; Rawlinson, William ; Koszinowski, Ulrich H.

Izvornik
Immunity (1074-7613) 6 (1997), 1; 57-66

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
murine cytomegalovirus; viral genes; cytomegalovirus glycoproteins; antigen presentation; MHC class I; immune evasion

Sažetak
The principle by which mouse cytomegalovirus blocks antigen presentation in the MHC class I pathway was investigated. The responsible gene m152, encoding a type I transmembrane glycoprotein of 40 kDa, is a member of a gene family located in the right-hand terminal region of the 230 kb virus genome. Expression of m152 in murine and human cells arrested the export of mouse class I complexes from the ER-Golgi intermediate compartment/cis-Golgi compartment and inhibited lysis by cytotoxic T cells. The plasma membrane transport of human MHC class I molecules was not affected. The deletion of the cytoplasmic tail of gp40 did not lift its effect on class I molecule export, indicating that this protein differs in its functions from known immunosubversive viral gene products and represents a novel principle by which a herpesvirus shuts off MHC class I function.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Veterinarska medicina

POVEZANOST RADA