Naslov
Amidated pectin-based wafers for econazole buccal delivery:Formulation optimization and antimicrobial efficacy estimation

Autori
Mura, Paola ; Mennini, Natascia ; Kosalec, Ivan ; Furlanetto, Sandra ; Orlandini, Serena ; Jug, Mario

Izvornik
Carbohydrate polymers (0144-8617) 121 (2015); 231-240

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Econazole nitrate; Sulphobutylether-ß-cyclodextrin; Low methoxy amidated pectin; Experimental design; Buccal wafer; Mucoadhesion

Sažetak
Combinations of low-methoxy amidated pectin (LMAP) and carboxymethylcellulose (CMC) were used to develop a lyophilized wafer formulation, aimed to obtain prolonged residence and controlled release of econazole nitrate (ECN) in the oral cavity. Ternary ECN/sulphobutylether-ß-cyclodextrin/citric acidcomplex, resulted as the most efficient system against selected Candida strains, was loaded into this formulation. The final product with the desired and predicted quality was developed by an experimental design strategy. The experimental values of mucoadhesion strength (28.37 ± 0.04 mg/cm2) and residence time (88.1 ± 0.1 min) obtained for the optimized wafer formulation were very close to the predicted ones, thus demonstrating the actual reliability and usefulness of the assumed model in the preparation of buccal wafers. The optimized formulation provided a constant ECN in situ release of 5 mg/h and was efficacious against selected Candida strains in vitro. This clearly proved its potential as a novel effective delivery system for the therapy of oral candidiasis.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA