Naslov
Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

Autori
Curcic, Marijana ; Jankovic, Sasa ; Jacevic, Vesna ; Stankovic, Sanja ; Vucinic, Slavica ; Durgo, Ksenija ; Bulat, Zorica ; Antonijevic, Biljana

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 63 (2012), 3; 255-262

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BDE209; Cd; thyroid-stimulating hormone; thyroxin; triiodothyronin

Sažetak
The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid- stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg(-1), 7.5 mg kg(-1), or 15 mg kg(-1) b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg(-1), 2000 mg kg(-1), or 4000 mg kg(-1) b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.

Izvorni jezik
Engleski

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