Naslov
Modulators of osteogenic, inflammatory and apoptotic response in vascular calcification

Autori
Ćelić, Tanja ; Marić, Ivana ; Markić, Dean ; Španjol, Josip ; Gršković, Antun ; Bobinac, Dragica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3rd International Congress of Croatian Association for Protection of non Ionizing Radiation : Abstract book / - , 2009, Xx-xx

Skup
International Congress of Croatian Association for Protection of non Ionizing Radiation (3 ; 2009)

Mjesto i datum
Opatija, Hrvatska, 23.10.2009. - 25.10.2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
bone morphogenetic proteins

Sažetak
Vascular calcification is associated with older age, atherosclerosis, diabetes mellitus and chronic kidney disease. Recent studies show that bone formation proteins are involved in vascular calcification. This process is considered to be regulated similar as bone tissue mineralization. We demonstrated up regulation of bone morphogenetic protein-2 (BMP-2) and RANK ligand (RANKL) in calcified areas, both identified as favors of calcification. The inhibitor of calcification, osteoprotegerin (OPG) is present in non diseased arteries and decreased with calcification occurence. Our results also show increased expression of another postulated calcification inhibitor BMP-7 and osteopontin (OPN). OPN is negatively associated with decreasement of alfa SMA. Loss of alfa SMA is followed by osteogenic phenotype appearance in calcified vasculature.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA