Naslov
Microbiological decontamination of botanical raw materials and corresponding pharmaceutical products by irradiation

Autori
Katušin-Ražem, Branka ; Novak, Boris ; Ražem, Dušan

Izvornik
Radiation Physics and Chemistry (0969-806X) 62 (2001); 261-275

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Microbiological contamination; botanical raw materials; irradiation decontamination; herbs; radiosensitivity
(Microbiological contamination; botanical raw materials; irradiation dectontamination; herbs; radiosensitivity)

Sažetak
Microbial contamination typical of botanical raw materials used in the manufacture of pharmaceuticals decreases with the increasing level of processing, on going from flowers and leaves 104 - 108 CFU/g), to fruits and seeds (102 - 106 CFU/g), to liquid extracts (104 – 106 CFU/g), and to dry extracts (102 – 105 CFU/g). At the same time the resistivity of microflora to irradiation, expressed as a dose required for the first 90 % reduction, increases along the same assortment as 2, 4, 5 and 5 kGy, respectively. This results in doses between 4 and 30 kGy required to treat typical contamination, or between 10 and 40 kGy for a severe case. The contamination of final products, phyto-therapeutic ointments (104 – 107 CFU/g), is relatively sensitive to irradiation (Dfirst 90 % red = 1 kGy) and usually does not require doses higher than 8 kGy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA