Naslov
Health-related quality of life among patients with postmenopausal osteoporosis treated with weekly and monthly bisphosphonates

Autori
Kaštelan, Darko ; Vlak, Tonko ; Lozo, Petar ; Gradiser, Marina ; Mijić, Šime ; Nikolić, Tatjana ; Miškić, Blaženka ; Car, Dolores ; Tajsić, Gordana ; Dušek, Tina ; Jajić, Zrinka ; Grubišić, Frane ; Poljičanin, Tamara ; Bakula, Miro ; Džubur, Fedja ; Strizak-Ujević, Matilda ; Kadojić, Mira ; Radman, Maja ; Vugrinec, Mirela ; Kuster, Zrinka ; Pekez, Marijeta ; Radović, Endi ; Labar, Ljubica, Crnčević-Orlić, Željka ; Koršić, Mirko

Izvornik
Endocrine research (0743-5800) 35 (2010), 4; 165-173

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bisphosphonates ; osteoporosis ; quality of life ; EQ-5D ; OPTQoL

Sažetak
The present study was designed to assess the effect of monthly ibandronate on health-related quality of life (HR-QoL) in patients with postmenopausal osteoporo- sis previously treated with weekly bisphosphonates. HR-QoL was assessed by Euroqol (EQ-5D) and Osteoporosis Targeted Quality of Life (OPTQoL) questionnaires. The EQ- 5D questionnaire showed significant improvement associated with ibandronate treatment, occurring in mobility (p < 0.01), usual activity (p < 0.01), pain/discomfort (p < 0.05), and anxiety/depression (p < 0.05). In addition, ibandronate treatment considerably improved patients’ perceived health on a visual analog scale (p < 0.001). For the OPTQoL questionnaire, patients reported less physical difficulty (p < 0.001), fewer adaptations in their lives (p < 0.001), and less fear (p < 0.001) with ibandronate than with weekly bisphosphonates. The study demonstrated that patients who were transferred from weekly bisphosphonates to a monthly ibandronate experienced improved HR-QoL.

Izvorni jezik
Engleski

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