Naslov
Elevation of diffusing lung capacity (TLCO) in asthmatic children as a result of ventilation/perfusion disorder

Autori
Pavlov, Neven ; Dragišić-Ivulić, Slavica ; Tocilj, Jadranka ; Pavlov, Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Respiratory Journal / European Respiratory Society - Beč : European Respiratory Society, 2003, 495-495

Skup
13th ERS Annual Congress

Mjesto i datum
Beč, Austrija, 27.09.2003. - 01.10.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
diffusing lung capacity; ventilation/perfusion; asthma; children

Sažetak
Aims: To determine the disorder of ventilation/perfusion in children with mild and moderate asthma. Subjects and methods: In the prospective study (1996-2002) we followed up 298 children, aged 10.7±3 years, 81 healthy (Control) and 217 children with mild and moderate asthma. 121 were treated with inhaled steroid (fluticasone propionate 100–200 mcg daily), 31 with salbutamol (100 mcg daily as needed) and 65 with ketotifen (2 mg daily). During treatment we measured: diffusing lung capacity (TLCO, single breath method with carbon monoxide), alveolar volume (VA) and transfer coefficient (KCO). Results: Children with asthma had significantly higher TLCO (p<0.0001), VA (p=0.005) and KCO (p<0.0001) at the beginning of the treatment, which normalized during the treatment and after bronchodilatation (salbutamol) test. Apart from reversibility of inflammatory changes and their good response to bronchodilatation therapy, it shows the disorder of ventilation/perfusion in children with mild and moderate asthma. Conclusion: Due to the ventilation/perfusion disorder in children with mild and moderate asthma, the rest of alveolar-cappilary units are included, which results in elevation of TLCO. Good response to bronchodilatation therapy and inhaled steroid treatment confirms the reversibility of inflammatory changes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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