Naslov
The experimental model of sporadic Alzheimer's disease

Autori
Šalković-Petrišić, Melita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Drugi simpozij Hrvatskog društva za znanost o laboratorijskim životinjama s međunarodnim sudjelovanjem

Mjesto i datum
Zagreb, Hrvatska, 10.10.2014

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
sporadic Alzheimer's disease; animal model; streptozotocin; intracerebroventricular

Sažetak
Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder in the elderly which is responsible for 60-80% of all dementia cases. The vast majority of AD cases are of a sporadic origin (sAD), unknown cause and ineffective treatment which all indicate a need for in-depth research of sAD ethiopathogenesis and pathophysiology. Development of animal model which would mimic human sAD condition as much as possible seems to be the first step in this research since widely exploited transgenic mice AD models represent a rare, genetically caused familial AD form. Considering post-mortem findings of the insulin resistant brain state (IRBS) in sAD patients, induction of IRBS in animals by intracerebroventricular (icv) administration of streptozotocin (STZ, a compound selectively toxic to insulin producing/secreting and insulin receptor expressing cells), has been recognized as promising experimental approach. STZ-icv rat (as well as mice and monkey) model shares a numerous behavioural (cognitive deficits), neurochemical (cholinergic deficit, IRBS, tau hyperphosphorylation, oxidative stress), metabolic (brain glucose hypometabolism) and structural (neuroinflammation, pathological amyloid accumulation) similarities with sAD patients. Further characterization and validation of STZ-icv animal model which is still in progress, will hopefully facilitate animal-to-human data translational process and contribute to design of preclinical and clinical drug trials, finally leading to more effective disease modifying therapy of sAD. Supported by MZOŠ, DAAD and UKF.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA