Naslov
Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth regulating factor

Autori
Milković, Lidija ; Čipak Gašparović, Ana ; Žarković, Neven

Izvornik
Free radical research (1071-5762) 49 (2015), 7; 850-860

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
cell proliferation; growth regulation; hormesis; lipid peroxidation; oxidative stress

Sažetak
The reactive aldehyde 4-hydroxynonenal (HNE) is major bioactive marker of lipid peroxidation generated under oxidative stress from polyunsaturated fatty acids. Biomedical significance of HNE was first revealed in pathogenesis of various degenerative and malignant diseases. Thus, HNE was considered for decades only as cytotoxic molecule, “second toxic messenger of free radicals” responsible for numerous undesirable consequences of oxidative stress. However, the increase of knowledge on physiology of redox signaling revealed also desirable, physiological roles of HNE, especially in the field of cellular signaling pathways regulating proliferation, differentiation, and apoptosis. These pluripotent effects of HNE can be explained by its concentration-dependent interactions with the cytokine networks and complex cellular antioxidant systems also showing cell and tissue specificities. Therefore, this paper gives a comprehensive, yet short overview on HNE as pluripotent growth-regulating factor.

Izvorni jezik
Engleski

POVEZANOST RADA