Naslov
Flow cytometry detection of signaling molecules and ABCB1 in AML

Autori
Perkovic, Sanja ; Zadro, Renata ; Batinic, Josip ; Labar, Boris ; Batinic, Drago

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Cytometry Part B (Clinical Cytometry). 2012 ; 82B / - , 2012, 374-374

Skup
12th Euroconference on Clinical Cell Analysis

Mjesto i datum
Budimpešta, Mađarska, 11.09.2012. - 15.09.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
signaling pathways; ABCB1; acute myeloid leukemia

Sažetak
Our results confirm the published data on higher frequency of FLT3-ITD positivity in more mature AMLs (promyelocytic and monocytic form). It is known that P-gp expression and activity is associated with CD34 expression, so reverse association between P-gp and FLT3-ITD could be foreseen. Surprisingly, although some reports state FLT3-ITD signal is transduced downstream by Akt molecule, we found no evidence of that. Further analysis of signaling pathways activation with regard to of clinical characterization and patient’s survival and outcomes might contribute to the definition of novel prognostic markers in AML.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA