Naslov
Cathecol-0-methykl transferase and schizophrenia

Autori
Šagud, marina ; Muck-Šeler, Dorotea ; Mihaljević-peleš, Alam ; Vuksan-Ćusa, Bjanka ; Živković, Maja ; Jakovljević, Miro ; Pivac, Nela

Izvornik
Psychiatria Danubina (0353-5053) 22 (2010), 2; 270-274

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
COMT Val108/158Met polymorphism; schizophrenia; response to antipsychotics

Sažetak
Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity. It is particularely important in prefrontal cortex, since COMT activity is the most important regulator of the prefrontal dopamine function. Given the association between schizophrenia and decreased dopamine activity in the prefrontal cortex, it is not surprising that Val108/158Met polymorphism is among the most extensively investigated polymorphisms in schizophrenia. According to different studies, Val allele may be a small risk factor for schizophrenia. There is also some evidence that Val108/158Met polymorphism influences the age of onset of schizophrenia, cognitive function, severity of psychotic symptoms, as well as efficacy and adverse events of antipsychotics. Heterogenity of patient population has undoubtedly influenced the results of these studies. Interaction of Val108/158Met polymorphism with other genes and environmental factors is an important avenue for future research.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je prezentiran na skupu.

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