Naslov
Epidermal growth factor receptor (EGFR) expression in patients with laryngeal squamous cell carcinoma

Autori
Kontić, Mirko ; Milovanović, Jovica ; Poljak, Nikola Kolja ; Sučić, Ante ; Šundov, Željko ; Pešutić Pisac, Valdi

Izvornik
European archives of oto-rhino-laryngology (0937-4477) 272 (2015), 2; 401-405

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Epidermal growth factor receptor (EGFR); laryngeal squamous cell carcinoma.
(Epidermal growth factorreceptor (EGFR); laryngeal squamous cell carcinoma)

Sažetak
To assess the epidermal growth factor receptor (EGFR) correlation with histopathologic and clinical characteristics of laryngeal squamous cell carcinoma (SCC) and the impact of EGFR overexpression on patient survival. This retrospective study included 185 SCC patients treated at Clinical Department of ENT, Head and Neck Surgery, Split University Hospital Center between January 1, 2000 and December 31, 2009. A statistically significant correlation (p < 0.001) was recorded between the level of EGFR expression and SCC histopathologic grade, stage, metastasizing potential, relapsing potential, and patient survival. Kaplan-Meier survival curve yielded a statistically significant difference (χ 2 = 75.05 ; p < 0.001) among the four patient groups with different levels of EGFR expression. The higher the level of EGFR expression, the poorer is the patient prognosis and survival. In our study, expression of EGFR as a biomarker showed a potential predictive value in laryngeal SCC.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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