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Pregled bibliografske jedinice broj: 739647

The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus-mediated inflammatory cardiomyopathy

Klingel, Karin; Fabritius, C.; Sauter, Martina; Göldner, K.; Stauch, D.; Kandolf, R.; Ettischer, N.; Gahlen, S.; Schönberger, T.; Ebner, S. et al.
The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus-mediated inflammatory cardiomyopathy // Journal of pathology, 234 (2014), 2; 164-177 doi:10.1002/path.4369 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 739647 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus-mediated inflammatory cardiomyopathy

Autori
Klingel, Karin ; Fabritius, C. ; Sauter, Martina ; Göldner, K. ; Stauch, D. ; Kandolf, R. ; Ettischer, N. ; Gahlen, S. ; Schönberger, T. ; Ebner, S. ; Makrigiannis, A. P. ; Bélanger, S. ; Diefenbach, A. ; Polić, Bojan ; Pratschke, J. ; Kotsch, K.

Izvornik
Journal of pathology (0022-3417) 234 (2014), 2; 164-177

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NKG2D; natural killer cells; virus-induced cardiomyopathy

Sažetak
In enterovirus-induced cardiomyopathy, information regarding the detailed impact of natural killer (NK) cells on the outcome of the disease is limited. We therefore hypothesized that NK cells and certain NK cell receptors determine the different outcome of coxsackievirus B3 (CVB3) myocarditis. Here, we demonstrate in murine models that resistance to chronic CVB3 myocarditis in immunocompetent C57BL/6 mice is characterized by significantly more mature CD11b(high) NK cells, the presence of NKG2D on NK cells, and enhanced NKG2D-dependent cytotoxicity compared to CVB3-susceptible A.BY/SnJ mice. The highly protective role of NKG2D in myocarditis was further proven by in vivo neutralization of NKG2D as well as in NKG2D-deficient mice but was shown to be independent of CD8(+) T-cell-dependent immunity. Moreover, the adoptive transfer of immunocompetent C57BL/6 NK cells pre- (day -1) as well as post-infectionem (day +2) displayed the potential to prevent permissive A.BY/SnJ mice from a progressive outcome of CVB3 myocarditis reflected by significantly improved cardiopathology and heart function. Altogether, our results provide firm evidence for a protective role of NKG2D-activated NK cells in CVB3 myocarditis leading to an effective virus clearance, thus offering novel therapeutic options in the treatment of virus-induced myocarditis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
062-0621261-1271 - Uloga NKG2D u razvoju, homeostazi i efektorskim funkcijama imunološkog sustava (Polić, Bojan, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Bojan Polić (autor)

Poveznice na cjeloviti tekst rada:

doi onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Klingel, Karin; Fabritius, C.; Sauter, Martina; Göldner, K.; Stauch, D.; Kandolf, R.; Ettischer, N.; Gahlen, S.; Schönberger, T.; Ebner, S. et al.
The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus-mediated inflammatory cardiomyopathy // Journal of pathology, 234 (2014), 2; 164-177 doi:10.1002/path.4369 (međunarodna recenzija, članak, znanstveni)
Klingel, K., Fabritius, C., Sauter, M., Göldner, K., Stauch, D., Kandolf, R., Ettischer, N., Gahlen, S., Schönberger, T. & Ebner, S. (2014) The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus-mediated inflammatory cardiomyopathy. Journal of pathology, 234 (2), 164-177 doi:10.1002/path.4369.
@article{article, author = {Klingel, Karin and Fabritius, C. and Sauter, Martina and G\"{o}ldner, K. and Stauch, D. and Kandolf, R. and Ettischer, N. and Gahlen, S. and Sch\"{o}nberger, T. and Ebner, S. and Makrigiannis, A. P. and B\'{e}langer, S. and Diefenbach, A. and Poli\'{c}, Bojan and Pratschke, J. and Kotsch, K.}, year = {2014}, pages = {164-177}, DOI = {10.1002/path.4369}, keywords = {NKG2D, natural killer cells, virus-induced cardiomyopathy}, journal = {Journal of pathology}, doi = {10.1002/path.4369}, volume = {234}, number = {2}, issn = {0022-3417}, title = {The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus-mediated inflammatory cardiomyopathy}, keyword = {NKG2D, natural killer cells, virus-induced cardiomyopathy} }
@article{article, author = {Klingel, Karin and Fabritius, C. and Sauter, Martina and G\"{o}ldner, K. and Stauch, D. and Kandolf, R. and Ettischer, N. and Gahlen, S. and Sch\"{o}nberger, T. and Ebner, S. and Makrigiannis, A. P. and B\'{e}langer, S. and Diefenbach, A. and Poli\'{c}, Bojan and Pratschke, J. and Kotsch, K.}, year = {2014}, pages = {164-177}, DOI = {10.1002/path.4369}, keywords = {NKG2D, natural killer cells, virus-induced cardiomyopathy}, journal = {Journal of pathology}, doi = {10.1002/path.4369}, volume = {234}, number = {2}, issn = {0022-3417}, title = {The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus-mediated inflammatory cardiomyopathy}, keyword = {NKG2D, natural killer cells, virus-induced cardiomyopathy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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