Naslov
Novel whole blood biocompatible device OSTEOGROW – BMP6

Autori
Grgurević, Lovorka ; Pećina, Marko ; Jelić, Mislav ; Jankolija, Morana ; Brkljačić, Jelena ; Vukičević, Slobodan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Final Program / - , 2014

Skup
XXVI SICOT Triennial World Congress combined with the 46 SBOT Annual Meeting

Mjesto i datum
Rio de Janeiro, Brazil, 19.11.2014. - 22.11.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
BMP-6; OSTEOGROW

Sažetak
Purpose: The purpose of this study was to explore the mechanism of action and efficacy of low BMP6 doses in a novel whole blood biocompatible device OSTEOGROW.Methods: BMP6 function has been assessed in Bmp6-/- mice by μCT and skeletal histology, and has also been examined in mesenchymal stem cells (MSC), hematopoietic stem cells (HSC) and osteoclasts. Safety and efficacy of OSTEOGROW have been assessed in rats and rabbits.Results: OSTEOGROW required small amounts of BMP6, applied in a biocompatible blood coagulum carrier, for stimulating differentiation of MSCs and accelerated healing of critical size bone defects in animals, without bone resorption and inflammation. BMP6 decreased the number of osteoclasts derived from HSC, while BMP2 and BMP7 increased their number.Conclusions: Current issues and challenges with commercial bone devices may be resolved by using novel BMP6 biocompatible device OSTEOGROW, which will be clinically tested in metaphyseal bone fractures, compartments where BMP2 and BMP7 have not been effective.

Izvorni jezik
Engleski

POVEZANOST RADA